About this talk

Part of the webinar series Unravelling T Cell Recognition: Insights from Immunology and AI. T cells recognise specific antigens in cancer, infection, and autoimmunity through highly diverse T cell receptors (TCRs), yet systematically mapping TCR specificity at scale remains a major challenge in immunology. In this webinar, Dr Stephanie Gaglione (Gladstone Institutes) will present new scalable experimental and functional screening platforms designed to decode antigen-specific T cell recognition. The talk will cover TCRAFT, a modular approach for rapid large-scale TCR reconstruction while preserving native chain pairing, alongside RAPTR and VelociRAPTR technologies for high-throughput receptor–ligand screening across millions of TCR variants and peptide antigens. These approaches provide new opportunities to understand, engineer, and therapeutically manipulate antigen-specific immune responses across autoimmunity, infection, and cancer immunotherapy. Hosted by Prof Hashem Koohy, Associate Professor of Systems Immunology, University of Oxford.

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