Breakthroughs using gene therapy and gene editing are regularly in the news, but how close in reality are we to them to be used to treat actual patients? Professor of Molecular Therapy and Co-Director of the Gene Medicine Research Group, Steve Hyde sorts the fact from the fiction as he discusses how viruses are being re-purposed to treat rare diseases such as leukaemia, blindness and haemophilia.

Big data and AI are starting to feature in cancer research today, and will will play an even greater role in the future. Join researchers from Cancer Research UK to discover the technologies and methods they use to help find, prevent and treat cancer, and what big ideas they have for the future.

IF Oxford is operating a Pay What You Decide (PWYD) ticketing system. This works by enabling you to pre-book events without paying for a ticket beforehand. Afterwards, you have the opportunity to pay what you decide you want to, or can afford. If you prefer, you can make a donation to IF Oxford when you book. All funds raised go towards next year’s Festival.

Geographers have long been interested in the spaces brought into being by the internet. In the early days of the Web, digital technologies were seen as tools that could bring a heterotopic cyberspace into being: a place beyond space de-tethered from the material world.

More recent framings instead see digital geographies as always-augmented, hybrid, and ontogenetic: integrally embedded into everyday life.

Against that backdrop, Professor Mark Graham will present findings from three large research projects about digital platforms. First, a large-scale digital mapping project that looks at how digital inequalities can become infused into our urban landscapes. Second, a study about the livelihoods of platform workers in Southeast Asia and Sub-Saharan Africa. Finally, early results from a new action research project (the Fairwork Foundation) designed to improve the quality of platform jobs.

In each case, the talk explores why understanding the ways that platforms command digital geographies is a crucial prerequisite for envisioning more equitable digital futures.

Please register via the link provided. This talk will be followed by a drinks reception, all welcome.

As part of the Surgical Grand Round lecture series, hosted by the Nuffield Department of Surgical Sciences, Mr Vincent Gnanapragasam from the University of Cambridge will discuss ‘Using research to change paradigms in diagnosing and managing early prostate cancer’.

Charles Babbage has been called the ‘great-uncle’ of modern computing, a claim that rests simultaneously on his demonstrable understanding of most of the architectural principles underlying the modern computer,band the almost universal ignorance of Babbage’s work before 1970. There has since been an explosion of interest both in Babbage’s devices and the impact they might have had in some parallel history, and in Babbage himself as a man of great originality who had essentially no influence at all on subsequent technological development.

In all this, one fundamental question has been largely ignored: how is it that one individual working alone could have synthesised a workable computer design over a short period, designing an object whose complexity of behaviour so far exceeded that of contemporary machines that it would not be matched for over one hundred years?

Our Leverhulme funded project Notions and notations: Charles Babbage’s language of thought investigated the design methods that Babbage used, and their impact on subsequent design practice. As part of that work we constructed a steam-driven difference engine to Babbage’s outline design.

In this general interest talk, we shall describe some aspects of Babbage’s designs and design methods, and demonstrate the difference engine.

As part of the Surgical Grand Round lecture series, hosted by the Nuffield Department of Surgical Sciences, Professor Chris Lavy from the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences will present ‘Public-private partnerships in elective surgery’.

The logic and principles behind the drive for evidence-based health care are so compelling that often the limitations of evidence go unacknowledged. Despite a strong evidence base demonstrating the health risks associated with higher body weights, and health professionals routinely instructing patients to lose weight to improve their health, the incidence of obesity is predicted to continue to rise. Calling on his research into the relationships between obesity, inequality and health, Oli Williams – a fellow of The Healthcare Improvement Studies Institute – will argue that when it comes to reducing the burden on, and improving, health care a more critical approach to the way we generate, select, apply and communicate evidence is needed.

Oli Williams completed his PhD in the Department of Sociology at the University of Leicester. He was subsequently awarded the NIHR CLAHRC West Dan Hill Fellowship in Health Equity which he held at the University of Bath. He later re-joined the University of Leicester in the Department of Health Sciences working in the SAPPHIRE Group and is now based at King’s College London after being awarded a THIS Institute Postdoctoral Fellowship. His research focuses on health inequalities, the promotion of healthy lifestyles, obesity, weight stigma, equitable intervention and co-production. He co-founded the art collective Act With Love (AWL) to promote social change. The Weight of Expectation comic is one example of their work, view others at: www.actwithlove.co.uk In recognition of his work on weight stigma the British Science Association invited Oli to deliver the Margaret Mead Award Lecture for Social Sciences at the British Science Festival 2018.

This talk is being held as part of the Qualitative Research Methods course which is part of the Evidence-Based Health Care Programme. This is a free event and members of the public are welcome to attend.

Join us to learn about the progress being made in biomaterials, the next generation of innovative solutions that aim to tackle current health challenges, and what it takes to start your own venture. The event will feature talks from two prominent individuals, Dr Nick Skaer (CEO of Orthox) and Dr Nick Edwards (Co-Founder of MedInnovate and Chairman of Satie8). Dr Skaer has over 25 years’ experience in life science and materials research, and 14 years as a medtech CEO, raising over £18m. Dr Edwards has over 30 years’ experience in supporting pharmaceutical companies as ex- Global Lead of Accenture’s Pharmaceutical R&D business and current Chairman of Prescient Healthcare Group. He is a Founder of MedInnovate and an investor and supporter of life-science start-ups as well as current Chairman of Satie8.

There will be a networking & drinks reception after the event.

The event is free as always. Spots are limited, so get registered today on:

https://www.eventbrite.co.uk/e/the-next-generation-of-medical-devices-tickets-76955848013

This is an exclusive event brought to you by the SIU in partnership with the Oxford Pharmacology Society. The application of big data and genomics in healthcare is vast, with tremendous opportunities to revolutionise current methods of diagnosing and treating diseases. Although, patient specific data is a powerful tool that can accelerate the development and translation of novel drugs and therapeutics, there are limitations to overcome. This event will take a closer look at the role of industries, academics, clinicians and healthcare policy makers in encouraging the translation of ideas into real-world solutions and the challenges within each sector. To discuss this, we will be hosting Dr Jeffrey Barrett (CSO and Director of Genomics Plc), Dr Michelle van Velthoven (Sir David Cooksey Fellow in Healthcare Translation at the University of Oxford) and Dr Amitava Banerjee (Associate Professor in Clinical Data Science at University College London).
The event will be on the 20th November at 17h30pm – 19h00, in the Department of Pharmacology. There will be a free networking & drinks reception after the event.
The event is free as always. Spots are limited, so get registered today on https://www.eventbrite.co.uk/e/pharma-and-big-data-the-healthcare-revolution-tickets-80628276345

This talk will describe a class of machine learning methods for reasoning about complex physical systems. The key insight is that many systems can be represented as graphs with nodes connected by edges. I’ll present a series of studies which use graph neural networks–deep neural networks that approximate functions on graphs via learned message-passing-like operations– to predict the movement of bodies in particle systems, infer hidden physical properties, control simulated robotic systems, and build physical structures. These methods are not specific to physics, however, and I’ll show how we and others have applied them to broader problem domains with rich underlying structure.

Should doctors with commercial interests lead research on their products? Should we forget ‘conflicts’ and discuss ‘declarations of interest’ instead? Who should hold and maintain conflicts of interest registers for doctors? Should practicing doctors work with the pharma industry as well as serve on guideline committees? Should researchers with extensive financial interests be disqualified from studies of their own products?

The Physician Payments Sunshine Act requires US manufacturers to collect, track and report all financial relationships with clinicians and teaching hospitals. Professor Heneghan will discuss the failings with the current system of reporting of conflicts in medicine, what’s been tried so far, and why it is time for a UK Sunshine Act.

Carl Heneghan, Professor of Evidence-Based Medicine, employs evidence-based methods to research diagnostic reasoning, test accuracy and communicating diagnostic results to a wider audience.

This talk is being held as part of the Practice of Evidence-Based Health Care module which is part of the MSc in Evidence-Based Health Care and the MSc in EBHC Systematic Reviews. Members of the public are welcome to attend.

Overdiagnosis is the diagnosis of “disease” that will never cause symptoms or death during a patient’s lifetime.

Recent results of the NELSON Lung Cancer Screening Trial reports reductions in lung-cancer survival but not overall survival – The desire to detect disease even earlier means Overdiagnosis is on the rise, however, the interpretation of screening trial results is problematic and often gives rise to significant uncertainties that go unanswered.

Carl Heneghan, Professor of Evidence-Based Medicine, employs evidence-based methods to research diagnostic reasoning, test accuracy and communicating diagnostic results to a wider audience.

This talk is being held as part of the Evidence-Based Diagnosis & Screening module which is part of the MSc in Evidence-Based Health Care and the MSc in EBHC Medical Statistics. Members of the public are welcome to attend.

In this book talk, Claas will review central findings of his research on the past 80 years of antibiotic use, resistance, and regulation in food production with introduction by Prof Mark Harrison, Director of Wellcome Centre for Ethics and Humanities.

Mass-introduced after 1945, antibiotics helped revolutionise food production. Farmers and veterinarians used antibiotics to prevent and treat disease, protect plants, preserve food, and promote animals’ growth. Many soon became dependent on routine antibiotic use to sustain and increase production. The resulting growth of antibiotic infrastructures came at a price. Critics blamed antibiotics for leaving dangerous residues in food, enabling bad animal welfare, and selecting for antimicrobial resistance (AMR) in bacteria, which could no longer be treated with antibiotics.

Pyrrhic Progress analyses over 80 years of evolving non-human antibiotic use on both sides of the Atlantic and introduces readers to the historical and current complexities of antibiotic stewardship in a time of rising AMR.

This talk includes a drinks reception and nibbles, all welcome

In modern high-tech health care, patients appear to be the stumbling block.

Uninformed, anxious, noncompliant individuals with unhealthy lifestyles who demand treatments advertised by celebrities and insist on unnecessary but expensive diagnostics may eventually turn into plaintiffs. But what about their physicians? About ten years ago, Muir Gray and Gerd Gigerenzer published a book with the subtitle “Envisioning health care 2020”. They listed “seven sins” of health care systems then, one of which was health professionals’ stunning lack of risk literacy. Many were not exactly sure what a false-positive rate was, or what overdiagnosis and survival rates mean, and they were unable to evaluate articles in their own field. As a consequence, the ideals of informed consent and shared decision-making remain a pipedream – both doctors and patients are habitually misled by biased information in health brochures and advertisements. At the same time, the risk literacy problem is one of the few in health care that actually have a known solution. A quick cure is to teach efficient risk communication that fosters transparency as opposed to confusion, both in medical school and in CME. It can be done with 4th graders, so it should work with doctors, too.

Now, in 2020, can every doctor understand health statistics? In this talk, Gerd Gigerenzer will describe the efforts towards this goal, a few successes, but also the steadfast forces that undermine doctors’ ability to understand and act on evidence. Moreover, the last decade has seen two new forces that distract from solving the problem. The first is the promise of digital technology, from diagnostic AI systems to big data analytics, which consumes much of the attention. Digital technology is of little help if doctors do not understand it. Second, our efforts to make patients competent and to encourage them to articulate their values are now in conflict with the new paternalistic view that patients just need to be nudged into better behaviour.

This talk will be followed by a drinks reception, all welcome

Joint event with: The Oxford–Berlin Research Partnership

Lecture by Jinny Blom who has created over 250 gardens and landscapes, Laurent-Perrier garden which gained a Gold at Chelsea. Artist in Residence for Chelsea & Westminster Hospital, she is author of The Thoughtful Gardener: An intelligent approach to garden design (2017). Pay at the door; registration not required.

With the UK population predicted to grow nearly 20% by 2050 (circa 77 million people), over 65s making up around 25% of the population and more and more demands being put on the healthcare system what does the future hold?

Professor Chris Whitty, England’s Chief Medical Officer, will discuss predictions for the future advancement of healthcare in the UK and how these advancements will monitor, diagnose and treat us and how this will change our healthcare system.

Part of the Oxford Martin School Lecture Series: ‘Shaping the future’

Snakebite is arguably the world’s biggest hidden health crisis. It kills some 120,000 people every year, mostly from the world’s poorest communities in rural Africa, Asia and South America. The burden of death and disability is equivalent to that of prostate cancer or cervical cancer and greater than that of any other neglected tropical disease. Yet the problem is solvable – we need to bring snakebite treatment into the 21st century; we need innovative approaches to discovering and developing next generation snakebite treatments; and we need to build and importantly, sustain snakebite as a global health priority.

Dr Nick Cammack was appointed to the Wellcome Trust in September 2019 to lead an ambitious new £80 million programme aimed at driving a step-change in snakebite treatment around the world. The goal is to achieve a 50% reduction in mortality by 2030. In addition there is a pressing need to modernise the production of anti-venoms and improve their means of delivery.

Talk, followed by walking tour of the park. Jane Kilsby, local historian shares her
recent research into this well-loved 19th century public park. Maximum 20

Adults make choices regarding the technology they use to self-manage their health and wellbeing, and these technologies are often adopted, used and abused in ways that researchers, manufacturers, and clinicians have not accounted for. This talk will give an overview of human-computer interaction qualitative research on the real world use of mobile technologies in people’s everyday lives. Accounting for individual health and wellbeing choices adults make with technology, supporting choices through end user customisation, and the emerging trend towards Do-It-Yourself open-source health and wellbeing technology will be discussed. Examples of pragmatic qualitative studies will be given from research on wearables, apps, and standalone devices used for Type 1 diabetes, hearing loss, baby monitoring, and physical fitness.

Dr Aisling O’Kane is a Senior Lecturer in Human-Computer Interaction for Health and Deputy Director of the EPSRC CDT in Digital Health and Care at the University of Bristol. As a member of the Bristol Interaction Group and the Digital Health Engineering Group, she uses a pragmatic approach to qualitative research of health, wellbeing and care technologies. Dr O’Kane is currently PI of Innovate UK Machine Learning for Diabetes, co-designing AI to support diabetes self-management and Co-I of EPSRC SPHERE Next Steps, co-designing smart home technology to support health at home.

This talk is being held as part of the Advanced Qualitative Research Methods course which is part of the Evidence-Based Health Care Programme. This is a free event and members of the public are welcome to attend.

What happens when new artificial intelligence (AI) tools are integrated into organisations around the world?

For example, digital medicine promises to combine emerging and novel sources of data and new analysis techniques like AI and machine learning to improve diagnosis, care delivery and condition management. But healthcare workers find themselves at the frontlines of figuring out new ways to care for patients through, with – and sometimes despite – their data. Paradoxically, new data-intensive tasks required to make AI work are often seen as of secondary importance. Gina calls these tasks data work, and her team studied how data work is changing in Danish & US hospitals (Moller, Bossen, Pine, Nielsen and Neff, forthcoming ACM Interactions).

Based on critical data studies and organisational ethnography, this talk will argue that while advances in AI have sparked scholarly and public attention to the challenges of the ethical design of technologies, less attention has been focused on the requirements for their ethical use. Unfortunately, this means that the hidden talents and secret logics that fuel successful AI projects are undervalued and successful AI projects continue to be seen as technological, not social, accomplishments.

In this talk we will examine publicly known “failures” of AI systems to show how this gap between design and use creates dangerous oversights and to develop a framework to predict where and how these oversights emerge. The resulting framework can help scholars and practitioners to query AI tools to show who and whose goals are being achieved or promised through, what structured performance using what division of labour, under whose control and at whose expense. In this way, data work becomes an analytical lens on the power of social institutions for shaping technologies-in-practice.

Lecture by Linda Farrar, a freelance researcher, lecturer and author of Ancient Roman Gardens. The art of gardening has a long history, with gardens being used in most ancient cultures to enhance living areas, and even public spaces. We will look at examples from a range of ancient societies. Pay at the door or book online

Tea/coffee, biscuits on arrival in the Committee Room. Introductory talk from Sophie Huxley, Gardener, LMH, followed by tour of the garden. Parking for 5 cars only (priority to Blue Card holders). Maximum 20 persons

Friday 23 October

Lecture by Advolly Richmond. Thomas Birch was a trained botanist, and
head gardener at Orwell Park, Ipswich, before travelling to the Gold Coast.
He became part of the international network of correspondents and plant
collectors relied upon by the Royal Botanic Gardens at Kew. This talk aims to
reveal the true extent of Birch Freeman’s horticultural and botanical legacy.
Pay at the
door: £5 (members) £8 (guests

Join Professor Chas Bountra, Professor of Translational Medicine and Professor Sir Charles Godfray as they discuss how the healthcare system has had to adapt due to the Covid-19 pandemic and what this means in the future.

Lecture by Hanna Zembrzycka-Kisiel, Principal Major Applications Officer at
South Oxfordshire and Vale of White Horse Councils. Hanna uses the research
insights of her recent MA Thesis to explore the reality of poor urban design
and the benefits of green spaces in our living environments, drawing on local
and international urban design projects for inspiration. Book online or pay at the door.

In this talk Professor Gina Neff, Oxford Internet Institute and Professor Ian Goldin, Oxford Martin School, will examine publicly known “failures” of AI systems to show how this gap between design and use creates dangerous oversights and to develop a framework to predict where and how these oversights emerge. The resulting framework can help scholars and practitioners to query AI tools to show who and whose goals are being achieved or promised through, what structured performance using what division of labour, under whose control and at whose expense. In this way, data work becomes an analytical lens on the power of social institutions for shaping technologies-in-practice.

In 2020, Governments around the world made the decision to lock down their country to help stop the spread of Covid-19. This led to teaching, meetings, conferences, contacting family and more being conducted from home via the internet.

How did this affect data being used across the world? Did the systems already in place stand-up to the pressure? Was our privacy compromised. As companies and families grapple with how much data they need, we find ourselves in the midst of these important moral deliberations. The pandemic is revealing just how complex the data inter-dependencies are when we need to respond effectively.

Join Sir Tim Berners-Lee, inventor of the World Wide Web, and Professor Sir Nigel Shadbolt, leading researcher in Artificial Intelligence (AI), as they discuss what we have learnt and in what new directions we need to head in the world of data architecture.

With COVID-19 vaccines on the horizon, attention again returns to the contentious topic of whether vaccination should be made mandatory.

Recent polling has resulted in worrying headlines about a lack of willingness to have a COVID-19 vaccine if it were available.

Are mandates the answer to ensure vaccine high uptake to end the pandemic? While still a hypothetical scenario, without yet having a safe and effective vaccine approved for use, this could change in the coming months. The question of introducing mandatory vaccination spans considerations of personal liberty, health decision-making, public health and policy, as well as the relationship between the state and its citizens. Join Professor Julian Savulescu and Dr Samantha Vanderslott to debate the ethical and public policy arguments for and against mandatory COVID-19 vaccination.

On the 30th November it was announced that the Artificial Intelligence computer programme AlphaFold had made a decisive breakthrough in the determination of the 3-D structures of proteins.

The announcement was immediately hailed as one of the major scientific advances of the decade.

Why is it important to understand the 3-D structures of protein, why are they difficult to construct, and what is the nature of AlphaFold’s advance? Why is this so exciting and what further advances in medicine and the other biosciences may result? To find out, join a conversation between Yvonne Jones, Director, Cancer Research UK Receptor Structure Research Group and Charles Godfray, Director, Oxford Martin School, who will explore these fascinating issues.

Lecture by Jane Owen, preceded by OGT’s Christmas drinks party.
Jane Owen, Founder Member of OGT, avid gardener, garden historian and
previously Deputy Editor of the Financial Times, gives us her personal take on
garden history – not to be missed! Doors open 6.30pm for wine or juice (inc), for lecture at 7pm. Book online or pay at the door.
door