The advent of super-resolution microscopy has created unprecedented opportunities to study the mammalian central nervous system, which is dominated by anatomical structures whose nanoscale dimensions critically influence their biophysical properties. I will present our recent methodological advances 1) to analyze dendritic spines in the hippocampus in vivo and 2) to visualize the extracellular space (ECS) of the brain. Using a two-photon–STED microscope equipped with a long working distance objective and ‘hippocampal window’ to reach this deeply embedded structure, we measured the density and turnover of spines on CA1 pyramidal neurons. Spine density was two times higher than reported by conventional two-photon microscopy; around 40% of all spines turned over within 4 days. A combination of 3D-STED microscopy and fluorescent labeling of the extracellular fluid allows super-resolution shadow imaging (SUSHI) of the ECS in living brain slices. SUSHI enables quantitative analyses of ECS structure and produces sharp negative images of all cellular structures, providing an unbiased view of unlabeled brain cells in live tissue.

Dr Katherine Wheelhouse did her MChem at Jesus College, Oxford, working in the chemistry department with Prof Tim Donohoe before joining GSK as a process chemist in 2008. Since 2011 Katherine has specialised in application of chemical catalysis to pharmaceutical manufacture. She is a GSK scientific fellow, a member of the RSC Applied Catalysis Committee and also of the editorial advisory board of the journal Organic Process Research and Development. Katherine is going to talk about what it is that process chemists do (to enable doing things bigger) and how this fits into the development of medicines, illustrating with some examples from recent projects.

The talk is free for OUSS members, or £2 on the door. Membership can be obtained on the night or on our website. Those interested in meeting the speaker for dinner after the talk may contact oxforduniscisoc@gmail.com. eng

This is a joint event with the Oxford Energy Colloquia

Since the late 2000s, science has established that global warming is largely defined by the total amount of carbon dioxide we emit into the atmosphere. This concept not only implies that halting warming to any level implies that global carbon dioxide emissions have to be reduced to net zero, it also allows to estimate carbon budgets that would be compatible with limiting warming to either 1.5°C or 2°C. Once established, the carbon budget concept and its implications were rapidly taken up in policy discussions.

In this talk, Dr Joeri Rogelj, will explore and discuss the latest developments in estimation the remaining carbon budget as well as its usefulness for guiding policy and climate change mitigation action.

This talk will be followed by a drinks reception, all welcome

Warburg Memorial Lecture – Joint with BBOWT
Bryophytes in Cambridgeshire have been recorded continuously since 1927 and with increasing intensity in recent decades. A detailed analysis of the records reveals the remarkably dynamic nature of the bryophyte flora of lowland England.

‘Triboreacted materials as functional interfaces in internal combustion engines and medical implants’

Reducing CO2 and particulate emissions to halt global warming and improve the air cleanliness in developed and developing nations is urgent. A similarly large challenge is the provision of medical implants that will serve the ageing population. Both challenges are underpinned by the need to understand important functional interfaces.
This talk will focus on the engine and the hip and will present how an understanding of the interactions between tribology and chemistry/corrosion play a crucial role in the interfacial friction, wear and integrity. The integration of state-of-the-art surface science with engineering simulations in both of these areas enables engineers to create optimised systems with improved performance

Newspapers often feature studies that sound too good to be true and often they aren’t – they are myths.

Some myths may be harmless but the phenomenon affects most kinds of research within evidence-based science. The good news is that there’s a new movement tackling misleading and unreliable research and instead trying to give us results that we can trust.

Using his research in to human pheromones as an example, Tristram will discuss how and why popular myths, including power-posing, are created and how efforts have been made to address the ‘reproducibility crisis’.

Tristram Wyatt is an emeritus fellow of Kellogg College, Oxford and formerly Director of Studies in Biology at OUDCE. He is currently a Senior Research Fellow at the Department of Zoology, University of Oxford. He’s interested in how animals of all kinds use pheromones to communicate by smell. His Cambridge University Press book on pheromones and animal behaviour won the Royal Society of Biology’s prize for the Best Postgraduate Textbook in 2014. His TED talk on human pheromones has been viewed over a million times. His book Animal behaviour: A Very Short Introduction was published by Oxford University Press in 2017.

Open to all. The talk is designed for researchers from all disciplines and is open to the public.

The economic case for limiting warming to 1.5°C is unclear, due to manifold uncertainties. However, it cannot be ruled out that the 1.5°C target passes a cost-benefit test. Costs are almost certainly high: the median global carbon price in 1.5°C scenarios implemented by various energy models is more than US$100 per metric ton of CO2 in 2020, for example. Benefits estimates range from much lower than this to much higher. Some of these uncertainties may reduce in the future, raising the question of how to hedge in the near term.

Simon Dietz is an environmental economist with particular interests in climate change and sustainable development. He has published dozens of research articles on a wide range of issues, and he also works with governments, businesses and NGOs on topics of shared interest, such as carbon pricing, insurance and institutional investment.

In mammals the cell-autonomous circadian clock pivots around a transcriptional/post-translational feedback loop. However, we remain largely ignorant of the critical molecular, cell biological, and circuit-level processes that determine the precision and robustness of circadian rhythms: what keeps them on track, and what determines their period, which varies by less than 5 minutes over 24 hours? The origin of this precision and robustness is the suprachiasmatic nucleus (SCN) of the basal hypothalamus, the principal circadian pacemaker of the brain. The SCN sits atop a circadian hierarchy that sustains and synchronises the innumerable cell-autonomous clocks of all major organs to solar time (and thereby to each other), by virtue of direct retinal innervation that entrains the transcriptional oscillator of the 20,000 or so component cells of the SCN. I shall describe real-time imaging approaches to monitor circadian cycles of gene expression and cellular function in the SCN, and intersectional genetic and pharmacological explorations of the cell-autonomous and circuit-level mechanisms of circadian timekeeping. A particular focus will be on “translational switching” approaches to controlling clock function and the surprising discovery of a central role for SCN astrocytes in controlling circadian behaviour.

The day will consist of a range of events, hosted by speakers from different areas of STEM and industry. Expect to hear from keynote speakers, engage with panel discussions, and get hands on experience in smaller workshops focusing on entrepreneurship, outreach, disabilities and more.

Don’t miss out on hearing from a range of speakers, including: Dr. Chonnettia Jones, Director of Insight and Analysis at the Wellcome Trust; Prof. Daniela Bortoletto, Professor of Physics at Brasenose; plus Oxford’s own Vice Chancellor, Louise Richardson.

Everyone is welcome, regardless of gender, year and subject.

For more information visit OxFEST’s facebook page: https://www.facebook.com/events/294126621288050/

Join us at Teddy Hall next week for a fantastic event on the ‘Neuroscience of Dance’ brought to you by the Centre for the Creative Brain!

Science, dance and wine – what more could you want for a Saturday afternoon?

A few (free) tickets are still available, so be quick!

https://www.seh.ox.ac.uk/discover/research/centre-for-the-creative-brain

Join astrobiologist Lewis Dartnell as he takes us billions of years into our planet’s past and tells us the ultimate origin story. From the cultivation of the first crops to the founding of modern states, Lewis reveals the Earth’s awesome impact on the shape of human civilizations.

How are the Himalayas linked to the orbit of the Earth? Or to the formation of the British Isles? Humans are often thought to shape the environment around us, but as a species the environment shapes us. Geological forces drove evolution in East Africa; mountainous terrain led to the development of the democracy in Greece; and today voting behaviour in the United States follows the bed of an ancient sea. So come along and find out How the Earth Made Us – and made Donald Trump the US president!

Lewis Dartnell is an astrobiology researcher and professor at the University of Westminster. He has won several awards for his science writing and contributes to the Guardian, The Times and New Scientist. He has also written for television, appeared on BBC Horizon, Sky News and Wonders of the Universe as well as National Geographic and History channels. He is also author of the bestselling book The Knowledge: How to Rebuild our World From Scratch.

Lewis will be signing copies of his book Origins – How the Earth Made Us at the end the end of the event.

Suitable for ages 16+

Automation, AI and robotics are changing our lives quickly – but digital disruption goes much further than we realise.

In this talk, Richard Baldwin, one of the world’s leading globalisation experts, will explain that exponential growth in computing, transmission and storage capacities is also creating a new form of ‘virtual’ globalisation that could undermine the foundations of middle-class prosperity in the West.

This book talk will be followed by a drinks reception and book signing, all welcome.

In 2013, Carl Frey and Michael Osborne published a paper titled ‘The Future of Employment: How Susceptible Are Jobs to Computerisation?’ which estimated that 47% of jobs in the US are at risk of automation.

In this talk Dr Carl Benedikt Frey, Co-Director of the Oxford Martin Programme on Technology and Employment, will discuss the societal consequences of the accelerating pace of automation, and what we can learn from previous episodes of worker-replacing technological change.

This is a joint lecture with The Rockefeller Foundation Economic Council on Planetary Health at the Oxford Martin School

Cooling is critical for many of the sustainable development goals, including those relating to health, shelter, livelihoods, education and nutrition. As the world’s population grows, as disposable incomes grow and as urban areas grow, the need for cooling is booming. However cooling uses super polluting gases and large amounts of energy and is therefore a significant cause of climate change. More efficient, clean cooling has the potential to avoid up to a degree of warming by the end of the century and recently all governments came together to agree action to try to maximize this opportunity. Cooling sits at the intersection of the UNFCCC, the SDGs and the Montreal Protocol, but can these forces ensure success?

Dan Hamza-Goodacre will explain the risks and possibilities in the search for sustainable cooling for all.

This talk will be followed by a drinks reception, all welcome

Currently limited tools exist to accurately forecast the complex nature of disease spread across the globe. Dr Moritz Kraemer will talk about the dynamic global maps being built, at 5km resolution, to predict the invasion of new organisms under climate change conditions and continued unplanned urbanisation.

Dung beetles in the British Isles are a vital part of their associated ecosystems but have been historically rather overlooked probably due to their chosen habitat. Now our native dung beetles are finally beginning to get some of the invertebrate limelight due to an emphasis on ecosystem services and a much more environmentally friendly farming future. However we are lacking on a great deal of base data about these vitally important species and surveying is the one of the best ways to get information. This means getting into dung and discovering these unsung heroes

The Global Politics, Economy and Society (GPES) Research Centre at Oxford Brookes will be hosting its first annual lecture, given by the writer and activist George Monbiot. All welcome, but please book via the registration link.

The ecology and history of one of the largest atolls in the world. Aldabra, situated in the South West Indian Ocean, supports the largest population of giant tortoises worldwide. A UNESCO World Heritage Site, it is a stronghold for wildlife in a region that is besieged by threats.

Professor Dave Carter reveals how understanding intercellular communication could improve healthcare.

This is a joint event with the Oxford Martin School and the Oxford Climate Research Network (OCRN)

Professor David Battisti, The Tamaki Endowed Chair of Atmospheric Sciences, will be talking about global climate sensitivity controlling regional warming uncertainty and its role in impacting on human health, particularly heat stress.

The 11th Annual Human Welfare Conference is entitled ‘Innovate: Balancing Interests in Resource-Constrained Settings’. The conference will focus on solutions being developed at various scales to improve human wellbeing in areas as diverse as poverty alleviation, education, health, and social welfare. The goal is to offer diverse, interdisciplinary perspectives on tackling the most pertinent issues facing our society today. Invited speakers include academics and practitioners, with experience working in government, NGOs and the commercial sector in fields as diverse as health, food, investment and education.

This is a joint event with the Oxford Martin Programme on the Future of Food

Dr Mike Hamm will explore the opportunity for regional food systems in-and-around cities for mutual benefit. He will approach a number of issues – including vertical farming, bio-geochemical cycles, water use, new entry farmers, and healthy food provisioning – embedded in the notion of city region food systems with reference to supply/demand dynamics.

This talk will be followed by a drinks reception, all welcome

The 5th Annual Oxford Business and Poverty Conference will feature a diverse range of speakers addressing the Paradoxes of Prosperity. Sign up here: https://www.eventbrite.com/e/5th-annual-oxford-business-poverty-conference-tickets-57733957822
Hosted at the Sheldonian Theatre, the conference will feature keynotes by:
Lant Pritchett: RISE Research Director at the Blavatnik School of Government, former Senior Fellow at the Center for Global Development
Efosa Ojomo: Global Prosperity Lead and Senior Researcher at the Clayton Christensen Institute
John Hoffmire: Director of Center on Business and Poverty and Research Associate at Kellogg Colleges at Center For Mutual and Employee-owned Business at Oxford University
Ananth Pai: Executive Director, Bharath Beedi Works Pvt. Ltd. and Director, Bharath Auto Cars Pvt
Laurel Stanfield: Assistant Professor of Marketing at Bentley College in Massachusetts
Grace Cheng: Greater China’s Country Manager for Russell Reynolds Associates
Madhusudan Jagadish: 2016 Graduate MBA, Said Business School, University of Oxford
Tentative Schedule:
2:15-2:20 Welcome
2:20-2:50 Efosa Ojomo, co-author of The Prosperity Paradox, sets the stage for the need for innovation in development
2:50-3:20 John Hoffmire, Ananth Pai and Mudhusudan Jagadish explain how the Prosperity Paradox can be used in India as a model to create good jobs for poor women
3:20-3:40 Break
3:40-4:10 Laurel Steinfeld speaks to issues of gender, development and business – addressing paradoxes related to prosperity
4:10-4:40 Grace Cheng, speaks about the history of China’s use of disruptive innovations to develop its economy
4:40-5:15 Break
5:15-6 Lant Pritchett talks on Pushing Past Poverty: Paths to Prosperity
6:30-8 Dinner at the Rhodes House – Purchase tickets after signing up for the conference
Sponsors include: Russell Reynolds, Employee Ownership Foundation, Ananth Pai Foundation and others

Our wild bees and other pollinators are so important, but they are still the unsung heroes of the environment, gardens and countryside and continue to decline in number and range. The talk will identify what we can all do to help wild bees. Many of the actions we take to protect one pollinator species, such as flower rich habitat creation and reduction in pesticide use, will assist biodiversity as a whole.

News about Britain’s wildlife and ecosystems tends to be grim. In ‘Green and Prosperous Land’, Dieter Helm, a member of the Department of Food and Rural Affairs (DEFRA) and advisor to the government, shares a radical but tangible plan for positive change. This is not the pale shadow offered by the current government, but a bold generational plan, which assesses the environment as a whole, explains the necessity of protecting and enhancing our green spaces and offers a clear, economically viable strategy to put Britain on a greener path.

Join Dieter Helm in conversation with Kathy Willis, as he explores his recommendations on how we can rescue the British Countryside.

The high seas are under severe pressure from both direct and indirect human impacts, including the effects of over-fishing, plastic debris and climate change. In this talk, Prof Alex Rogers will present what a network of marine protected areas in the high seas might look like, protecting 30% of known conservation features and taking into account climate change impacts. We will also hear from Dr Gwilym Rowlands, who will consider how such a network of marine protected areas could be enforced and the potential benefits to the ocean.

Architectural designer and TV presenter Charlie Luxton joins Oxford based architecture and design cooperative Transition by Design for a talk on sustainable architecture and how Oxford can meet the need for affordable housing whilst limiting the impact on the natural environment.

Following the talk, there will be a panel discussion and Q&A.

This event is for anyone who is interested in or currently building, renovating, converting or extending their home. The panel will include experts on architecture, housing and low-energy design in discussion on low-carbon materials and energy efficiency as well as co-housing, community-led design and other models of housing.

This event is part of Oxford Green Week 2019