The advent of super-resolution microscopy has created unprecedented opportunities to study the mammalian central nervous system, which is dominated by anatomical structures whose nanoscale dimensions critically influence their biophysical properties. I will present our recent methodological advances 1) to analyze dendritic spines in the hippocampus in vivo and 2) to visualize the extracellular space (ECS) of the brain. Using a two-photon–STED microscope equipped with a long working distance objective and ‘hippocampal window’ to reach this deeply embedded structure, we measured the density and turnover of spines on CA1 pyramidal neurons. Spine density was two times higher than reported by conventional two-photon microscopy; around 40% of all spines turned over within 4 days. A combination of 3D-STED microscopy and fluorescent labeling of the extracellular fluid allows super-resolution shadow imaging (SUSHI) of the ECS in living brain slices. SUSHI enables quantitative analyses of ECS structure and produces sharp negative images of all cellular structures, providing an unbiased view of unlabeled brain cells in live tissue.

Join us as part of St Anne’s Equalities Week in collaboration with Oxford Women in Business for a panel event featuring Anne’s alumni.
Under the banner of “Overcoming Challenges”, we shall discuss how best to navigate the world of work and whether diversity initiatives truly work.
After the panel event, there will be a drinks reception and an opportunity to meet the speakers.

Warburg Memorial Lecture – Joint with BBOWT
Bryophytes in Cambridgeshire have been recorded continuously since 1927 and with increasing intensity in recent decades. A detailed analysis of the records reveals the remarkably dynamic nature of the bryophyte flora of lowland England.

‘Triboreacted materials as functional interfaces in internal combustion engines and medical implants’

Reducing CO2 and particulate emissions to halt global warming and improve the air cleanliness in developed and developing nations is urgent. A similarly large challenge is the provision of medical implants that will serve the ageing population. Both challenges are underpinned by the need to understand important functional interfaces.
This talk will focus on the engine and the hip and will present how an understanding of the interactions between tribology and chemistry/corrosion play a crucial role in the interfacial friction, wear and integrity. The integration of state-of-the-art surface science with engineering simulations in both of these areas enables engineers to create optimised systems with improved performance

Newspapers often feature studies that sound too good to be true and often they aren’t – they are myths.

Some myths may be harmless but the phenomenon affects most kinds of research within evidence-based science. The good news is that there’s a new movement tackling misleading and unreliable research and instead trying to give us results that we can trust.

Using his research in to human pheromones as an example, Tristram will discuss how and why popular myths, including power-posing, are created and how efforts have been made to address the ‘reproducibility crisis’.

Tristram Wyatt is an emeritus fellow of Kellogg College, Oxford and formerly Director of Studies in Biology at OUDCE. He is currently a Senior Research Fellow at the Department of Zoology, University of Oxford. He’s interested in how animals of all kinds use pheromones to communicate by smell. His Cambridge University Press book on pheromones and animal behaviour won the Royal Society of Biology’s prize for the Best Postgraduate Textbook in 2014. His TED talk on human pheromones has been viewed over a million times. His book Animal behaviour: A Very Short Introduction was published by Oxford University Press in 2017.

Open to all. The talk is designed for researchers from all disciplines and is open to the public.

In mammals the cell-autonomous circadian clock pivots around a transcriptional/post-translational feedback loop. However, we remain largely ignorant of the critical molecular, cell biological, and circuit-level processes that determine the precision and robustness of circadian rhythms: what keeps them on track, and what determines their period, which varies by less than 5 minutes over 24 hours? The origin of this precision and robustness is the suprachiasmatic nucleus (SCN) of the basal hypothalamus, the principal circadian pacemaker of the brain. The SCN sits atop a circadian hierarchy that sustains and synchronises the innumerable cell-autonomous clocks of all major organs to solar time (and thereby to each other), by virtue of direct retinal innervation that entrains the transcriptional oscillator of the 20,000 or so component cells of the SCN. I shall describe real-time imaging approaches to monitor circadian cycles of gene expression and cellular function in the SCN, and intersectional genetic and pharmacological explorations of the cell-autonomous and circuit-level mechanisms of circadian timekeeping. A particular focus will be on “translational switching” approaches to controlling clock function and the surprising discovery of a central role for SCN astrocytes in controlling circadian behaviour.

Join us at Teddy Hall next week for a fantastic event on the ‘Neuroscience of Dance’ brought to you by the Centre for the Creative Brain!

Science, dance and wine – what more could you want for a Saturday afternoon?

A few (free) tickets are still available, so be quick!

https://www.seh.ox.ac.uk/discover/research/centre-for-the-creative-brain

Currently limited tools exist to accurately forecast the complex nature of disease spread across the globe. Dr Moritz Kraemer will talk about the dynamic global maps being built, at 5km resolution, to predict the invasion of new organisms under climate change conditions and continued unplanned urbanisation.

This book talk is co-organised with the Oxford Martin Programme on Collective Responsibility for Infectious Disease

Vaccination raises ethical issues about the responsibilities of individuals, communities, and states in preventing serious and potentially life-threatening infectious diseases. Such responsibilities are typically taken to be about minimising risks for those who are vaccinated and for those around them. However, there are other ethical considerations that matter when defining the responsibilities of different actors with regard to vaccination. Such ethical considerations are not often given due considerations in the debate on vaccination ethics and policy.

Thus, in this talk Dr Alberto Giubilini aims at offering a defence of compulsory vaccination taking into account not only the importance of preventing the harms of infectious diseases, but also the value of fairness in the distribution of the burdens entailed by the obligation to protect people from infectious diseases. He will offer a philosophical account of the key notions involved in the ethical debate on vaccination, of the types of responsibilities involved, of the possible types of vaccination policies ranked from the least to the most restrictive, and of the reasons why compulsory vaccination is, from an ethical point of view, the best policy available, as it is the most likely to guarantee not only protection from infectious diseases, but also a fair distribution of the burdens and responsibilities involved.

The talk will be followed by a drinks reception, all welcome

According to leading psychiatrist Jonathan Shay whose patients are US war veterans, “Moral injury is an essential part of any combat trauma that leads to lifelong psychological injury. Veterans can usually recover from horror, fear and grief so long as ”what’s right” has also not been violated”. The focus of this paper is on moral injury in both military combatants and police officers. The role of combatants and that of police officer both necessarily involve the use of harmful methods – paradigmatically, the use of lethal force in the case of combatants, the use of coercive force, deception and the like in the case of police officers – in the service of good ends, notably national self-defence and law enforcement, respectively. However, the use of these methods sets up a dangerous moral dynamic, including so-called dirty hands/dirty harry scenarios, and the possibility of the erosion of moral character – and, in some cases, moral injury.

Professor Bill (KWM) Fulford, Fellow of St Catherine’s College and Member of the Philosophy Faculty, University of Oxford, Emeritus Professor of Philosophy and Mental Health, University of Warwick, Director of the Collaborating Centre for Values-based practice, St Catherine’s College, Oxford, and Founder Editor and Chair of the Advisory Board, Philosophy, Psychiatry, & Psychology.
Abstract:
The widely held belief that the diagnosis of mental disorder is a matter exclusively for value-free science has been much reinforced by recent dramatic advances in the neurosciences. In this lecture I will use a detailed case study of delusion and spiritual experience to indicate to the contrary that values come into the diagnosis of mental disorders directly through the language of the diagnostic criteria adopted in such scientifically–grounded classifications as the American Psychiatric Association’s DSM (Diagnostic and Statistical Manual). Various competing interpretations of the importance of values in psychiatric diagnosis will be considered. Interpreted through the lens of the Oxford tradition of linguistic-analytic philosophy, however, diagnostic values in psychiatry are seen to reflect the complex and often conflicting values of real people. This latter interpretation has the direct consequence that there is a need for processes of assessment in psychiatry that are equally values-based as evidence-based. A failure to recognise this in the past has resulted in some of the worst abusive misuses of psychiatric diagnostic concepts. In the final part of the presentation I will outline recent developments in values-based practice in mental health, including some of its applications to diagnostic assessment, and in other areas of health care (such as surgery)

Dung beetles in the British Isles are a vital part of their associated ecosystems but have been historically rather overlooked probably due to their chosen habitat. Now our native dung beetles are finally beginning to get some of the invertebrate limelight due to an emphasis on ecosystem services and a much more environmentally friendly farming future. However we are lacking on a great deal of base data about these vitally important species and surveying is the one of the best ways to get information. This means getting into dung and discovering these unsung heroes

The ecology and history of one of the largest atolls in the world. Aldabra, situated in the South West Indian Ocean, supports the largest population of giant tortoises worldwide. A UNESCO World Heritage Site, it is a stronghold for wildlife in a region that is besieged by threats.

Professor Dave Carter reveals how understanding intercellular communication could improve healthcare.

The 11th Annual Human Welfare Conference is entitled ‘Innovate: Balancing Interests in Resource-Constrained Settings’. The conference will focus on solutions being developed at various scales to improve human wellbeing in areas as diverse as poverty alleviation, education, health, and social welfare. The goal is to offer diverse, interdisciplinary perspectives on tackling the most pertinent issues facing our society today. Invited speakers include academics and practitioners, with experience working in government, NGOs and the commercial sector in fields as diverse as health, food, investment and education.

This is a joint event with the Oxford Martin Programme on the Future of Food

Dr Mike Hamm will explore the opportunity for regional food systems in-and-around cities for mutual benefit. He will approach a number of issues – including vertical farming, bio-geochemical cycles, water use, new entry farmers, and healthy food provisioning – embedded in the notion of city region food systems with reference to supply/demand dynamics.

This talk will be followed by a drinks reception, all welcome

The 5th Annual Oxford Business and Poverty Conference will feature a diverse range of speakers addressing the Paradoxes of Prosperity. Sign up here: https://www.eventbrite.com/e/5th-annual-oxford-business-poverty-conference-tickets-57733957822
Hosted at the Sheldonian Theatre, the conference will feature keynotes by:
Lant Pritchett: RISE Research Director at the Blavatnik School of Government, former Senior Fellow at the Center for Global Development
Efosa Ojomo: Global Prosperity Lead and Senior Researcher at the Clayton Christensen Institute
John Hoffmire: Director of Center on Business and Poverty and Research Associate at Kellogg Colleges at Center For Mutual and Employee-owned Business at Oxford University
Ananth Pai: Executive Director, Bharath Beedi Works Pvt. Ltd. and Director, Bharath Auto Cars Pvt
Laurel Stanfield: Assistant Professor of Marketing at Bentley College in Massachusetts
Grace Cheng: Greater China’s Country Manager for Russell Reynolds Associates
Madhusudan Jagadish: 2016 Graduate MBA, Said Business School, University of Oxford
Tentative Schedule:
2:15-2:20 Welcome
2:20-2:50 Efosa Ojomo, co-author of The Prosperity Paradox, sets the stage for the need for innovation in development
2:50-3:20 John Hoffmire, Ananth Pai and Mudhusudan Jagadish explain how the Prosperity Paradox can be used in India as a model to create good jobs for poor women
3:20-3:40 Break
3:40-4:10 Laurel Steinfeld speaks to issues of gender, development and business – addressing paradoxes related to prosperity
4:10-4:40 Grace Cheng, speaks about the history of China’s use of disruptive innovations to develop its economy
4:40-5:15 Break
5:15-6 Lant Pritchett talks on Pushing Past Poverty: Paths to Prosperity
6:30-8 Dinner at the Rhodes House – Purchase tickets after signing up for the conference
Sponsors include: Russell Reynolds, Employee Ownership Foundation, Ananth Pai Foundation and others

Coriander Theatre presents a new play ‘My Mother Runs in Zig-Zags’ at the North Wall Arts Centre, 30th May – 1st June 2019, 7:30pm, Saturday Matinee 2:30pm.

Sometimes, race and trauma are like leaky old pipes: you can’t even have a friend over for dinner without something spilling out everywhere and flooding your life in the most unexpected way.

A conversation between friends becomes a journey to the Lebanese and Nigerian civil wars. Half-remembered worlds of violent oral history invade the kitchen and layer themselves over everyday life, shining light on the laughter that heals intergenerational traumas, and celebrating the overflowings and excesses of a life shaped by migration.

With an original musical score, a chorus of performance poets and contemporary dancers, and stories passed on from a generation of migrants, My mother runs in zig-zags is a bold new tragicomedy, devised by the best of Oxford University’s BAME actors and performers.

Age Guidance: 12+

My mother runs in zig zags

Our wild bees and other pollinators are so important, but they are still the unsung heroes of the environment, gardens and countryside and continue to decline in number and range. The talk will identify what we can all do to help wild bees. Many of the actions we take to protect one pollinator species, such as flower rich habitat creation and reduction in pesticide use, will assist biodiversity as a whole.

The high seas are under severe pressure from both direct and indirect human impacts, including the effects of over-fishing, plastic debris and climate change. In this talk, Prof Alex Rogers will present what a network of marine protected areas in the high seas might look like, protecting 30% of known conservation features and taking into account climate change impacts. We will also hear from Dr Gwilym Rowlands, who will consider how such a network of marine protected areas could be enforced and the potential benefits to the ocean.

The question of how far a state should authorise the peacetime collection and use of intelligence gathered by secret agents and by interception of communications has long been a thorny issue of public policy. Today, new ethical and legal questions arise from the ability to access in bulk personal information from social media and from Internet use and to apply artificial intelligence trained algorithms to mine data for intelligence and law enforcement purposes. In his talk Sir David Omand, a former director of GCHQ, will lay out an ethical framework for thinking about these powerful developments in modern digital intelligence.

Speaker: Professor Sir David Omand GCB is a visiting professor in the War Studies Department, King’s College London and at PSIA, Sciences Po, Paris. He was previously UK Security and Intelligence Coordinator, Permanent Secretary of the Home Office and Director, GCHQ. He is the author of Securing the State (Hurst, 2020) and, with Professor Mark Phythian, Principled Spying: the Ethics of Secret Intelligence, (Oxford University Press, 2018).

Dr Larkman is a retired Oxford biologist who has been chairman of OOS for the last 5 years. His main interest is the precipitous decline in the UK’s small, seed-eating farmland birds over the last 50 years.

For this event, 12 artists from all over the country will be presenting work that they have been making as part of the Sound Diaries open call.

The presenting artists are:

Richard Bentley, Hannah Dargavel-Leafe, Aisling Davis, Atilio Doreste, Marlo De Lara, Beth Shearsby, Kathryn Tovey, Jacek Smolicki, James Green, Lucia Hinojosa, Sena Karahan, Fi.Ona

Sound Diaries expands awareness of the roles of sound and listening in daily life. The project explores the cultural and communal significance of sounds and forms a research base for projects executed both locally and Internationally, in Beijing, Brussels, Tallinn, Cumbria and rural Oxfordshire.

The ability to accurately identify and interpret Track and Sign rests on a body of traditional knowledge that previous generations of naturalists would have regarded as fundamental. Sadly, now it is largely unknown and untaught, but with the upsurge of Citizen Science, it is perhaps more relevant than ever.

Slime moulds thrive in damp woodlands and normally spread over rotting logs eating bacteria and fungi. They are also unusual in being single giant cells that show remarkably sophisticated behaviour considering their humble form. This talk presents a little vignette of the science behind these curious beasts and how it has led to better understanding of other networked systems, and even the origins of civilisation.

Tenor Mark Padmore is preparing to take on the role of Aschenbach in David McVicar’s production of Benjamin Britten’s Death in Venice at the Royal Opera House. Join Mark and a panel of experts, including Colin Matthews, Ray Ockenden, John Hopkins, Henry Bacon, and Philip Bullock to explore this many-faceted character through literature, film, and opera.

2019 marks the 100th anniversary of the Brazilian composer Claudio Santoro (1919-1989), one of the major figures in twentieth-century Brazilian music. His musical legacy includes nearly five hundred compositions. Among them there are fourteen symphonies, several chamber works, concertos, vocal compositions, one opera, film scores, and seventy-three known works for piano solo. Beginning with his very first compositions, his intense and extremely idealistic personality, always searching for new ideas and new musical expressions, led him to explore diverse idioms in his music. This unmissable lecture recital will be presented by the composer’ son Alessandro Santoro, acclaimed harpsichordist and pianist, Brazilian soprano Gabriella Di Laccio and Dr Vinicius Mariano de Carvalho, Lecturer in Brazilian Studies, King’s College London. The concert will present some of Santoro Love Songs – an exquisite cycle written in partnership with Brazilian poet Vinicius de Moraes – as well some of Santoro’s piano preludes.