The advent of super-resolution microscopy has created unprecedented opportunities to study the mammalian central nervous system, which is dominated by anatomical structures whose nanoscale dimensions critically influence their biophysical properties. I will present our recent methodological advances 1) to analyze dendritic spines in the hippocampus in vivo and 2) to visualize the extracellular space (ECS) of the brain. Using a two-photon–STED microscope equipped with a long working distance objective and ‘hippocampal window’ to reach this deeply embedded structure, we measured the density and turnover of spines on CA1 pyramidal neurons. Spine density was two times higher than reported by conventional two-photon microscopy; around 40% of all spines turned over within 4 days. A combination of 3D-STED microscopy and fluorescent labeling of the extracellular fluid allows super-resolution shadow imaging (SUSHI) of the ECS in living brain slices. SUSHI enables quantitative analyses of ECS structure and produces sharp negative images of all cellular structures, providing an unbiased view of unlabeled brain cells in live tissue.

Warburg Memorial Lecture – Joint with BBOWT
Bryophytes in Cambridgeshire have been recorded continuously since 1927 and with increasing intensity in recent decades. A detailed analysis of the records reveals the remarkably dynamic nature of the bryophyte flora of lowland England.

‘Triboreacted materials as functional interfaces in internal combustion engines and medical implants’

Reducing CO2 and particulate emissions to halt global warming and improve the air cleanliness in developed and developing nations is urgent. A similarly large challenge is the provision of medical implants that will serve the ageing population. Both challenges are underpinned by the need to understand important functional interfaces.
This talk will focus on the engine and the hip and will present how an understanding of the interactions between tribology and chemistry/corrosion play a crucial role in the interfacial friction, wear and integrity. The integration of state-of-the-art surface science with engineering simulations in both of these areas enables engineers to create optimised systems with improved performance

Newspapers often feature studies that sound too good to be true and often they aren’t – they are myths.

Some myths may be harmless but the phenomenon affects most kinds of research within evidence-based science. The good news is that there’s a new movement tackling misleading and unreliable research and instead trying to give us results that we can trust.

Using his research in to human pheromones as an example, Tristram will discuss how and why popular myths, including power-posing, are created and how efforts have been made to address the ‘reproducibility crisis’.

Tristram Wyatt is an emeritus fellow of Kellogg College, Oxford and formerly Director of Studies in Biology at OUDCE. He is currently a Senior Research Fellow at the Department of Zoology, University of Oxford. He’s interested in how animals of all kinds use pheromones to communicate by smell. His Cambridge University Press book on pheromones and animal behaviour won the Royal Society of Biology’s prize for the Best Postgraduate Textbook in 2014. His TED talk on human pheromones has been viewed over a million times. His book Animal behaviour: A Very Short Introduction was published by Oxford University Press in 2017.

Open to all. The talk is designed for researchers from all disciplines and is open to the public.

In mammals the cell-autonomous circadian clock pivots around a transcriptional/post-translational feedback loop. However, we remain largely ignorant of the critical molecular, cell biological, and circuit-level processes that determine the precision and robustness of circadian rhythms: what keeps them on track, and what determines their period, which varies by less than 5 minutes over 24 hours? The origin of this precision and robustness is the suprachiasmatic nucleus (SCN) of the basal hypothalamus, the principal circadian pacemaker of the brain. The SCN sits atop a circadian hierarchy that sustains and synchronises the innumerable cell-autonomous clocks of all major organs to solar time (and thereby to each other), by virtue of direct retinal innervation that entrains the transcriptional oscillator of the 20,000 or so component cells of the SCN. I shall describe real-time imaging approaches to monitor circadian cycles of gene expression and cellular function in the SCN, and intersectional genetic and pharmacological explorations of the cell-autonomous and circuit-level mechanisms of circadian timekeeping. A particular focus will be on “translational switching” approaches to controlling clock function and the surprising discovery of a central role for SCN astrocytes in controlling circadian behaviour.

Talk followed by questions and discussion

All welcome

This is the latest in a series of eight weekly talks. The full list is:

Brexit: archaic techniques of ecstasy
Thursday 17 January: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

Shamanism: taking back control
Thursday 24 January: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

Tithe, timber, and the persistence of the ancien régime
Thursday 31 January: 7:30pm–9:00pm
Oxford Town Hall (St Aldates)

Hegelian dialectics and the prime numbers (part 2)
Thursday 7 February: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

Christopher Caudwell (1907–1937) and ‘the sources of poetry’
Thursday 14 February: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

Television: remote control
Thursday 21 February: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

Fascism and populism: can you spot the difference?
Thursday 28 February: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

The epos of everyday life
Thursday 7 March: 7:30pm–9:00pm
Wesley Memorial Church (New Inn Hall St)

The day will consist of a range of events, hosted by speakers from different areas of STEM and industry. Expect to hear from keynote speakers, engage with panel discussions, and get hands on experience in smaller workshops focusing on entrepreneurship, outreach, disabilities and more.

Don’t miss out on hearing from a range of speakers, including: Dr. Chonnettia Jones, Director of Insight and Analysis at the Wellcome Trust; Prof. Daniela Bortoletto, Professor of Physics at Brasenose; plus Oxford’s own Vice Chancellor, Louise Richardson.

Everyone is welcome, regardless of gender, year and subject.

For more information visit OxFEST’s facebook page: https://www.facebook.com/events/294126621288050/

Join us at Teddy Hall next week for a fantastic event on the ‘Neuroscience of Dance’ brought to you by the Centre for the Creative Brain!

Science, dance and wine – what more could you want for a Saturday afternoon?

A few (free) tickets are still available, so be quick!

https://www.seh.ox.ac.uk/discover/research/centre-for-the-creative-brain

Automation, AI and robotics are changing our lives quickly – but digital disruption goes much further than we realise.

In this talk, Richard Baldwin, one of the world’s leading globalisation experts, will explain that exponential growth in computing, transmission and storage capacities is also creating a new form of ‘virtual’ globalisation that could undermine the foundations of middle-class prosperity in the West.

This book talk will be followed by a drinks reception and book signing, all welcome.

Deborah Warner: Changing Directions – Journeys in theatre, opera and installation
Date: Wednesday, 27 February 2019
Time: 5.00pm (Attendees must be seated by 4.45pm)
Venue: Bernard Sunley Lecture Theatre, St Catherine’s College, Manor Road, Oxford, OX1 3UJ

Over her career, Deborah Warner has worked extensively in the fields of theatre, opera and classical music. Examples of her work as a Director include the plays Electra, King Lear and Richard II; and the operas The Turn of the Screw for the Royal Opera, which won the Evening Standard and South Bank Awards; Dido and Aeneas and La Traviata for the Vienna Festival. You can read more about Deborah Warner, and about the Cameron Mackintosh Visiting Professorship here.

Places for this event will be allocated by ballot. To register for the ballot, please complete the online form at www.stcatz.ox.ac.uk/deborahwarner by 12.00pm on Friday, 8 February. Please note that entry to the ballot does not automatically entitle applicants to a place at the lecture, but to a place in the draw. Printed confirmation of your ticket to the event will be required in order to attend the lecture.

You will be notified, via email, week commencing Monday, 18 February if you have been successful in securing a place at the lecture. Please contact development.office@stcatz.ox.ac.uk should you have any queries.

In 2013, Carl Frey and Michael Osborne published a paper titled ‘The Future of Employment: How Susceptible Are Jobs to Computerisation?’ which estimated that 47% of jobs in the US are at risk of automation.

In this talk Dr Carl Benedikt Frey, Co-Director of the Oxford Martin Programme on Technology and Employment, will discuss the societal consequences of the accelerating pace of automation, and what we can learn from previous episodes of worker-replacing technological change.

Currently limited tools exist to accurately forecast the complex nature of disease spread across the globe. Dr Moritz Kraemer will talk about the dynamic global maps being built, at 5km resolution, to predict the invasion of new organisms under climate change conditions and continued unplanned urbanisation.

ScreenTalk Oxfordshire proudly presents an evening with British Producer Jeremy Thomas. Jeremy has worked with renowned directors including Bertolucci, Nicolas Roeg, Jonathan Glazer and Ben Wheatley producing such great films as ‘The Last Emperor’, ‘Crash’, ‘Sexy Beast’ and ‘High-Rise’.

On Tuesday 5th March at the Lounge Bar, Curzon, Westgate Centre in Oxford, local producer Carl Schoenfeld will be talking to Jeremy Thomas about Directors, Actors, Crews as well as films he has produced and what he has learnt throughout his career.

Join us from 18:15 for a drink and chat in the bar, then at 19:00 with Carl Schoenfeld (ScreenTalk Co-Founder and Steering Group Member) in conversation with Jeremy Thomas (Recorded Picture Company).

There will be a Card/Cash Bar so join us after the talk to catch up and network.

ScreenTalk events are an opportunity to forge and strengthen contacts in Film, TV and Associated Media. For further information and to sign up to our mailing list please email screentalkoxfordshire@gmail.com

We expect this event to be popular and can only take pre-booked (free) tickets for entry.
Tickets: http://bit.ly/2GnlZhi

Dung beetles in the British Isles are a vital part of their associated ecosystems but have been historically rather overlooked probably due to their chosen habitat. Now our native dung beetles are finally beginning to get some of the invertebrate limelight due to an emphasis on ecosystem services and a much more environmentally friendly farming future. However we are lacking on a great deal of base data about these vitally important species and surveying is the one of the best ways to get information. This means getting into dung and discovering these unsung heroes

Blackwell’s are delighted to invite you to join us for a magical evening of light-hearted rehearsed readings as we step into the weird and wonderful world of The Fae.

“Fairy Tale” by Simon Josiffe is the story of a wild-living kelpie who’d rather be in the pub or on her motorbike but unfortunately has to look after us feckless mortals instead.

“Changeling” by Debs Wardle follows a woman who, on her 36th birthday, gets dragged into another realm and informed that she’s a faery who was swapped at birth with a human.

Both pieces will be read to you live by a talented cast of actors.

The ecology and history of one of the largest atolls in the world. Aldabra, situated in the South West Indian Ocean, supports the largest population of giant tortoises worldwide. A UNESCO World Heritage Site, it is a stronghold for wildlife in a region that is besieged by threats.

Professor Dave Carter reveals how understanding intercellular communication could improve healthcare.

In our first of two seminars on the future of work after automation Dr Brendan Burchell will investigate the potential for a five-day weekend society.

Machine-learning and robotics technologies promise to be able to replace some tasks or jobs that have traditionally been performed by humans. Like previous technologies introduced in the past couple of centuries, this possibility has been met with either optimism that will permit liberation from the tyranny of employment, or pessimism that it will lead to mass precarity and unemployment.

This presentation will draw upon both qualitative and quantitative evidence to explore the possible societal consequences of a radical reduction in the length of the normal working week. Drawing upon the evidence for the psychological benefits of employment, we look at the evidence for the minimum effective dose of employment. The paper also considers why the historical increases in productivity have not been matched with proportionate reductions in working time.

About Brendan Burchell:

Dr Brendan Burchell is a Reader in the Social Sciences in the Department of Sociology at the University of Cambridge. He is also a Fellow of Magdalene College, Cambridge.

Dr Burchell is director of graduate education for the Department of Sociology and director of the Cambridge Undergraduate Quantitative Research Centre. He was recently Head of Department for Sociology, as well as a Director of Studies and a Tutor at Magdalene College.

Dr Burchell’s main research interests centre on the effects of labour market conditions on wellbeing. Recent publications have focussed on unemployment, job insecurity, work intensity, part-time work, zero-hours contracts, debt, occupational gender segregation and self-employment. Most of his work concentrates on employment in Europe, but current projects also include an analysis of job quality, the future of work and youth self-employment in developing countries. He works in interdisciplinary environments with psychologists, sociologists, economists, lawyers and other social scientists.

Dr Burchell’s undergraduate degree was in Psychology, followed by a PhD in Social Psychology. His first post in Cambridge was a joint appointment between the social sciences and economics in 1985, and he has been in a permanent teaching post in at Cambridge since 1990.

Register:
https://www.eventbrite.co.uk/e/future-of-work-after-automation-towards-a-five-day-weekend-society-tickets-61028132788

This is a joint event with the Oxford Martin Programme on the Future of Food

Dr Mike Hamm will explore the opportunity for regional food systems in-and-around cities for mutual benefit. He will approach a number of issues – including vertical farming, bio-geochemical cycles, water use, new entry farmers, and healthy food provisioning – embedded in the notion of city region food systems with reference to supply/demand dynamics.

This talk will be followed by a drinks reception, all welcome

Is competition in the digital economy desirable? Does it currently exist? Is it possible? Is there anything policy can do?

This talk addresses all of these questions and presents the recommendations of the Digital Competition Expert Panel which was chaired by Jason Furman and recently presented its recommendations to the government.

On Wednesday 22 May, ScreenTalk Oxfordshire proudly presents Harnessing the Power of Video in Business Communications.
An evening with Tim May, MD of Strange Films and Music, talking with Toby Low – MD of MerchantCantos an international agency specialising in bringing creativity to critical business communications; Scott Shillum – CEO of Vismedia, Winner of the 2018 Digital Impact Awards and a pioneer in creating interactive, immersive content fused with cutting edge technology; Clare Holt – Founder of Nice Tree Films in Oxford and a member of ScreenTalk provides videos for businesses, public sector organisations, charities and education; Nicky Woodhouse – Founder of Woodhouse Video Production, award-winning female director of branded content and TVCs for online and broadcast.

Join us on Wednesday 22 May from 18:15 for a drink in the downstairs Lounge Bar, Curzon, Westgate Centre in Oxford, and why not try the Curzon’s excellent Pizza – great quality! At 19:00 Tim May will be talking to Toby Low, Scott Shillum, Clare Holt and Nicky Woodhouse. Afterwards there will be Shout Outs from ScreenTalk members and facilitated networking. At ScreenTalk events we run a Card/Cash Bar so please join us and take advantage of the opportunity to catch up and network.

We expect this event to be popular and can only take pre-booked (free) tickets for entry.

Join the conversation! ScreenTalk events are an opportunity to forge and strengthen contacts in Film, TV and Associated Media.
For further information and to sign up to our mailing list please email screentalkoxfordshire@gmail.com

Will a computer ever compose a symphony, write a prize-winning novel, or paint a masterpiece? And if so, would we be able to tell the difference? Marcus du Sautoy examines the nature of creativity, as well as providing an essential guide into how algorithms work, and the mathematical rules underpinning them. He asks how much of our emotional response to art is a product of our brains reacting to pattern and structure, and exactly what it is to be creative in mathematics, art, language and music.

This lecture is open to all, and is designed for researchers from all disciplines and members of the public. The lecture will take place in the Lecture Theatre at Rewley House, Oxford. Tea and coffee will be served in the Common Room from 4pm. The lecture will be followed by Q&As.

Marcus du Sautoy is the Simonyi Professor for the Public Understanding of Science and Professor of Mathematics at the University of Oxford. He is author of six books including his most recent books The Creativity Code (Fourth Estate 2019). He has presented numerous radio and TV series including a four part landmark TV series for the BBC called The Story of Maths. He works extensively with a range of arts organisations bringing science alive for the public from The Royal Opera House to the Glastonbury Festival. His play I is a Strange Loop (in which he is both actor and author) is part of the Barbican’s Life Rewired season. He received an OBE for services to science in the 2010 New Year’s Honours List and was made a Fellow of the Royal Society in 2016.

As part of the NIHR Oxford Biomedical Research Centre’s Open Day, a panel of experts will discuss how artificial intelligence can be used to benefit patients and the challenges that it presents. The discussion will be chaired by Professor Lionel Tarassenko, world-leading expert in the application of signal processing to medical systems.

The 5th Annual Oxford Business and Poverty Conference will feature a diverse range of speakers addressing the Paradoxes of Prosperity. Sign up here: https://www.eventbrite.com/e/5th-annual-oxford-business-poverty-conference-tickets-57733957822
Hosted at the Sheldonian Theatre, the conference will feature keynotes by:
Lant Pritchett: RISE Research Director at the Blavatnik School of Government, former Senior Fellow at the Center for Global Development
Efosa Ojomo: Global Prosperity Lead and Senior Researcher at the Clayton Christensen Institute
John Hoffmire: Director of Center on Business and Poverty and Research Associate at Kellogg Colleges at Center For Mutual and Employee-owned Business at Oxford University
Ananth Pai: Executive Director, Bharath Beedi Works Pvt. Ltd. and Director, Bharath Auto Cars Pvt
Laurel Stanfield: Assistant Professor of Marketing at Bentley College in Massachusetts
Grace Cheng: Greater China’s Country Manager for Russell Reynolds Associates
Madhusudan Jagadish: 2016 Graduate MBA, Said Business School, University of Oxford
Tentative Schedule:
2:15-2:20 Welcome
2:20-2:50 Efosa Ojomo, co-author of The Prosperity Paradox, sets the stage for the need for innovation in development
2:50-3:20 John Hoffmire, Ananth Pai and Mudhusudan Jagadish explain how the Prosperity Paradox can be used in India as a model to create good jobs for poor women
3:20-3:40 Break
3:40-4:10 Laurel Steinfeld speaks to issues of gender, development and business – addressing paradoxes related to prosperity
4:10-4:40 Grace Cheng, speaks about the history of China’s use of disruptive innovations to develop its economy
4:40-5:15 Break
5:15-6 Lant Pritchett talks on Pushing Past Poverty: Paths to Prosperity
6:30-8 Dinner at the Rhodes House – Purchase tickets after signing up for the conference
Sponsors include: Russell Reynolds, Employee Ownership Foundation, Ananth Pai Foundation and others

Coriander Theatre presents a new play ‘My Mother Runs in Zig-Zags’ at the North Wall Arts Centre, 30th May – 1st June 2019, 7:30pm, Saturday Matinee 2:30pm.

Sometimes, race and trauma are like leaky old pipes: you can’t even have a friend over for dinner without something spilling out everywhere and flooding your life in the most unexpected way.

A conversation between friends becomes a journey to the Lebanese and Nigerian civil wars. Half-remembered worlds of violent oral history invade the kitchen and layer themselves over everyday life, shining light on the laughter that heals intergenerational traumas, and celebrating the overflowings and excesses of a life shaped by migration.

With an original musical score, a chorus of performance poets and contemporary dancers, and stories passed on from a generation of migrants, My mother runs in zig-zags is a bold new tragicomedy, devised by the best of Oxford University’s BAME actors and performers.

Age Guidance: 12+

My mother runs in zig zags

Our wild bees and other pollinators are so important, but they are still the unsung heroes of the environment, gardens and countryside and continue to decline in number and range. The talk will identify what we can all do to help wild bees. Many of the actions we take to protect one pollinator species, such as flower rich habitat creation and reduction in pesticide use, will assist biodiversity as a whole.

Digital technologies are changing economics in two ways. The characteristics of an increasingly digital economy raise questions about economic analysis in domains ranging from competition policy to corporate finance, while new data sources and methodologies challenge economists to develop new empirical approaches.