The advent of super-resolution microscopy has created unprecedented opportunities to study the mammalian central nervous system, which is dominated by anatomical structures whose nanoscale dimensions critically influence their biophysical properties. I will present our recent methodological advances 1) to analyze dendritic spines in the hippocampus in vivo and 2) to visualize the extracellular space (ECS) of the brain. Using a two-photon–STED microscope equipped with a long working distance objective and ‘hippocampal window’ to reach this deeply embedded structure, we measured the density and turnover of spines on CA1 pyramidal neurons. Spine density was two times higher than reported by conventional two-photon microscopy; around 40% of all spines turned over within 4 days. A combination of 3D-STED microscopy and fluorescent labeling of the extracellular fluid allows super-resolution shadow imaging (SUSHI) of the ECS in living brain slices. SUSHI enables quantitative analyses of ECS structure and produces sharp negative images of all cellular structures, providing an unbiased view of unlabeled brain cells in live tissue.

FLJS Films is pleased to present a special screening of Golden Kingdom, the acclaimed first international feature film to be produced in Myanmar since its reopening. The film’s director Brian Perkins will discuss the film and its genesis, which included a campaign to partly crowdfund its production.

Set and shot in a remote monastery in Shan State — a region in which separatists have fought a decades-long war against the Myanmar government — Golden Kingdom follows the story of four young monks, each endearingly and intelligently played by local non-professional actors. When their simple life of meditation and play is interrupted by an urgent call to engage with the vastly more threatening environment of the country at large, the film depicts the physical and spiritual journey of one of the boys through the troubled country as civil strife breaks out.

Touching on themes of displacement and the quest for safe passage and refuge, and featuring exquisitely evocative sound design by Oscar nominee David C. Hughes (GONE GIRL, HER), Golden Kingdom subtly alludes to the wider geopolitical currents emerging in Myanmar, while avoiding easy answers in its enigmatic exploration of the beauty, spirituality, and fortitude of the country and its people.

We invite attendees to donate to the Médecins Sans Frontières/Doctors Without Borders (MSF) Rohingya Refugee Crisis appeal to provide vital healthcare to Rohingya refugees fleeing violence in Myanmar.

Praise for Golden Kingdom:

“Compelling and elegantly crafted throughout, and hugely evocative of an enclosed world with its own lore and beliefs.”
Jonathan Romney, Screen International

“Transporting …. Shimmering … Golden Kingdom is a more intimate appreciation of Buddhism than Martin Scorsese’s rapturous “Kundun” or Bernardo Bertolucci’s “Little Buddha”.”
Guy Lodge, Variety

Warburg Memorial Lecture – Joint with BBOWT
Bryophytes in Cambridgeshire have been recorded continuously since 1927 and with increasing intensity in recent decades. A detailed analysis of the records reveals the remarkably dynamic nature of the bryophyte flora of lowland England.

‘Triboreacted materials as functional interfaces in internal combustion engines and medical implants’

Reducing CO2 and particulate emissions to halt global warming and improve the air cleanliness in developed and developing nations is urgent. A similarly large challenge is the provision of medical implants that will serve the ageing population. Both challenges are underpinned by the need to understand important functional interfaces.
This talk will focus on the engine and the hip and will present how an understanding of the interactions between tribology and chemistry/corrosion play a crucial role in the interfacial friction, wear and integrity. The integration of state-of-the-art surface science with engineering simulations in both of these areas enables engineers to create optimised systems with improved performance

Newspapers often feature studies that sound too good to be true and often they aren’t – they are myths.

Some myths may be harmless but the phenomenon affects most kinds of research within evidence-based science. The good news is that there’s a new movement tackling misleading and unreliable research and instead trying to give us results that we can trust.

Using his research in to human pheromones as an example, Tristram will discuss how and why popular myths, including power-posing, are created and how efforts have been made to address the ‘reproducibility crisis’.

Tristram Wyatt is an emeritus fellow of Kellogg College, Oxford and formerly Director of Studies in Biology at OUDCE. He is currently a Senior Research Fellow at the Department of Zoology, University of Oxford. He’s interested in how animals of all kinds use pheromones to communicate by smell. His Cambridge University Press book on pheromones and animal behaviour won the Royal Society of Biology’s prize for the Best Postgraduate Textbook in 2014. His TED talk on human pheromones has been viewed over a million times. His book Animal behaviour: A Very Short Introduction was published by Oxford University Press in 2017.

Open to all. The talk is designed for researchers from all disciplines and is open to the public.

In mammals the cell-autonomous circadian clock pivots around a transcriptional/post-translational feedback loop. However, we remain largely ignorant of the critical molecular, cell biological, and circuit-level processes that determine the precision and robustness of circadian rhythms: what keeps them on track, and what determines their period, which varies by less than 5 minutes over 24 hours? The origin of this precision and robustness is the suprachiasmatic nucleus (SCN) of the basal hypothalamus, the principal circadian pacemaker of the brain. The SCN sits atop a circadian hierarchy that sustains and synchronises the innumerable cell-autonomous clocks of all major organs to solar time (and thereby to each other), by virtue of direct retinal innervation that entrains the transcriptional oscillator of the 20,000 or so component cells of the SCN. I shall describe real-time imaging approaches to monitor circadian cycles of gene expression and cellular function in the SCN, and intersectional genetic and pharmacological explorations of the cell-autonomous and circuit-level mechanisms of circadian timekeeping. A particular focus will be on “translational switching” approaches to controlling clock function and the surprising discovery of a central role for SCN astrocytes in controlling circadian behaviour.

From Afghanistan to Zimbabwe, UN agencies, NGOs and the Red Cross / Crescent work to save lives and protect rights in the wake of natural disasters and armed conflict. How effective is the $27Billion sector? And what challenges does it face? The Oxford launch event of the State of the Humanitarian System report, with expert panel and Q and A

Join us at Teddy Hall next week for a fantastic event on the ‘Neuroscience of Dance’ brought to you by the Centre for the Creative Brain!

Science, dance and wine – what more could you want for a Saturday afternoon?

A few (free) tickets are still available, so be quick!

https://www.seh.ox.ac.uk/discover/research/centre-for-the-creative-brain

Deborah Warner: Changing Directions – Journeys in theatre, opera and installation
Date: Wednesday, 27 February 2019
Time: 5.00pm (Attendees must be seated by 4.45pm)
Venue: Bernard Sunley Lecture Theatre, St Catherine’s College, Manor Road, Oxford, OX1 3UJ

Over her career, Deborah Warner has worked extensively in the fields of theatre, opera and classical music. Examples of her work as a Director include the plays Electra, King Lear and Richard II; and the operas The Turn of the Screw for the Royal Opera, which won the Evening Standard and South Bank Awards; Dido and Aeneas and La Traviata for the Vienna Festival. You can read more about Deborah Warner, and about the Cameron Mackintosh Visiting Professorship here.

Places for this event will be allocated by ballot. To register for the ballot, please complete the online form at www.stcatz.ox.ac.uk/deborahwarner by 12.00pm on Friday, 8 February. Please note that entry to the ballot does not automatically entitle applicants to a place at the lecture, but to a place in the draw. Printed confirmation of your ticket to the event will be required in order to attend the lecture.

You will be notified, via email, week commencing Monday, 18 February if you have been successful in securing a place at the lecture. Please contact development.office@stcatz.ox.ac.uk should you have any queries.

Currently limited tools exist to accurately forecast the complex nature of disease spread across the globe. Dr Moritz Kraemer will talk about the dynamic global maps being built, at 5km resolution, to predict the invasion of new organisms under climate change conditions and continued unplanned urbanisation.

ScreenTalk Oxfordshire proudly presents an evening with British Producer Jeremy Thomas. Jeremy has worked with renowned directors including Bertolucci, Nicolas Roeg, Jonathan Glazer and Ben Wheatley producing such great films as ‘The Last Emperor’, ‘Crash’, ‘Sexy Beast’ and ‘High-Rise’.

On Tuesday 5th March at the Lounge Bar, Curzon, Westgate Centre in Oxford, local producer Carl Schoenfeld will be talking to Jeremy Thomas about Directors, Actors, Crews as well as films he has produced and what he has learnt throughout his career.

Join us from 18:15 for a drink and chat in the bar, then at 19:00 with Carl Schoenfeld (ScreenTalk Co-Founder and Steering Group Member) in conversation with Jeremy Thomas (Recorded Picture Company).

There will be a Card/Cash Bar so join us after the talk to catch up and network.

ScreenTalk events are an opportunity to forge and strengthen contacts in Film, TV and Associated Media. For further information and to sign up to our mailing list please email screentalkoxfordshire@gmail.com

We expect this event to be popular and can only take pre-booked (free) tickets for entry.
Tickets: http://bit.ly/2GnlZhi

Dung beetles in the British Isles are a vital part of their associated ecosystems but have been historically rather overlooked probably due to their chosen habitat. Now our native dung beetles are finally beginning to get some of the invertebrate limelight due to an emphasis on ecosystem services and a much more environmentally friendly farming future. However we are lacking on a great deal of base data about these vitally important species and surveying is the one of the best ways to get information. This means getting into dung and discovering these unsung heroes

Blackwell’s are delighted to invite you to join us for a magical evening of light-hearted rehearsed readings as we step into the weird and wonderful world of The Fae.

“Fairy Tale” by Simon Josiffe is the story of a wild-living kelpie who’d rather be in the pub or on her motorbike but unfortunately has to look after us feckless mortals instead.

“Changeling” by Debs Wardle follows a woman who, on her 36th birthday, gets dragged into another realm and informed that she’s a faery who was swapped at birth with a human.

Both pieces will be read to you live by a talented cast of actors.

The ecology and history of one of the largest atolls in the world. Aldabra, situated in the South West Indian Ocean, supports the largest population of giant tortoises worldwide. A UNESCO World Heritage Site, it is a stronghold for wildlife in a region that is besieged by threats.

Professor Dave Carter reveals how understanding intercellular communication could improve healthcare.

This is a joint event with the Oxford Martin Programme on the Future of Food

Dr Mike Hamm will explore the opportunity for regional food systems in-and-around cities for mutual benefit. He will approach a number of issues – including vertical farming, bio-geochemical cycles, water use, new entry farmers, and healthy food provisioning – embedded in the notion of city region food systems with reference to supply/demand dynamics.

This talk will be followed by a drinks reception, all welcome

On Wednesday 22 May, ScreenTalk Oxfordshire proudly presents Harnessing the Power of Video in Business Communications.
An evening with Tim May, MD of Strange Films and Music, talking with Toby Low – MD of MerchantCantos an international agency specialising in bringing creativity to critical business communications; Scott Shillum – CEO of Vismedia, Winner of the 2018 Digital Impact Awards and a pioneer in creating interactive, immersive content fused with cutting edge technology; Clare Holt – Founder of Nice Tree Films in Oxford and a member of ScreenTalk provides videos for businesses, public sector organisations, charities and education; Nicky Woodhouse – Founder of Woodhouse Video Production, award-winning female director of branded content and TVCs for online and broadcast.

Join us on Wednesday 22 May from 18:15 for a drink in the downstairs Lounge Bar, Curzon, Westgate Centre in Oxford, and why not try the Curzon’s excellent Pizza – great quality! At 19:00 Tim May will be talking to Toby Low, Scott Shillum, Clare Holt and Nicky Woodhouse. Afterwards there will be Shout Outs from ScreenTalk members and facilitated networking. At ScreenTalk events we run a Card/Cash Bar so please join us and take advantage of the opportunity to catch up and network.

We expect this event to be popular and can only take pre-booked (free) tickets for entry.

Join the conversation! ScreenTalk events are an opportunity to forge and strengthen contacts in Film, TV and Associated Media.
For further information and to sign up to our mailing list please email screentalkoxfordshire@gmail.com

Released ten years ago on a (comparatively) minuscule budget, Duncan Jones’s eerie sci-fi debut became an instant cult classic. Set in a future where the energy crisis has been solved by mining fuel from the moon, Sam Rockwell plays the satellites’ sole worker. He spends his time fixing failing equipment, bickering with his AI companion, and speaking to his family back home – until he unearths a terrible truth with existentially catastrophic implications.

A Science Oxford Q&A with Prof Chris Lintott (Professor of Astrophysics in the Department of Physics at the University of Oxford and presenter of the BBC series The Sky at Night) follows this screening.

‘With its measured pacing, melancholy tone and eye for prosaic details, Moon is very different from the glossy sci-fi blockbuster – and far more satisfying.’ ★★★★ Wendy Ide, The Times

Dir. Duncan Jones. UK, 2009. 1h 37m. Starring Sam Rockwell, Kevin Spacey, Matt Berry, Robin Chalk, Dominique McElligott, Kaya Scodelario, Malcolm Stewart, Benedict Wong.

This event is part of a partnership between Science Oxford and the UPP in Oxford that aims to bring science and technology-themed activities to wider audiences across the region.

Coriander Theatre presents a new play ‘My Mother Runs in Zig-Zags’ at the North Wall Arts Centre, 30th May – 1st June 2019, 7:30pm, Saturday Matinee 2:30pm.

Sometimes, race and trauma are like leaky old pipes: you can’t even have a friend over for dinner without something spilling out everywhere and flooding your life in the most unexpected way.

A conversation between friends becomes a journey to the Lebanese and Nigerian civil wars. Half-remembered worlds of violent oral history invade the kitchen and layer themselves over everyday life, shining light on the laughter that heals intergenerational traumas, and celebrating the overflowings and excesses of a life shaped by migration.

With an original musical score, a chorus of performance poets and contemporary dancers, and stories passed on from a generation of migrants, My mother runs in zig-zags is a bold new tragicomedy, devised by the best of Oxford University’s BAME actors and performers.

Age Guidance: 12+

My mother runs in zig zags

Our wild bees and other pollinators are so important, but they are still the unsung heroes of the environment, gardens and countryside and continue to decline in number and range. The talk will identify what we can all do to help wild bees. Many of the actions we take to protect one pollinator species, such as flower rich habitat creation and reduction in pesticide use, will assist biodiversity as a whole.

The high seas are under severe pressure from both direct and indirect human impacts, including the effects of over-fishing, plastic debris and climate change. In this talk, Prof Alex Rogers will present what a network of marine protected areas in the high seas might look like, protecting 30% of known conservation features and taking into account climate change impacts. We will also hear from Dr Gwilym Rowlands, who will consider how such a network of marine protected areas could be enforced and the potential benefits to the ocean.

Dr Larkman is a retired Oxford biologist who has been chairman of OOS for the last 5 years. His main interest is the precipitous decline in the UK’s small, seed-eating farmland birds over the last 50 years.

For this event, 12 artists from all over the country will be presenting work that they have been making as part of the Sound Diaries open call.

The presenting artists are:

Richard Bentley, Hannah Dargavel-Leafe, Aisling Davis, Atilio Doreste, Marlo De Lara, Beth Shearsby, Kathryn Tovey, Jacek Smolicki, James Green, Lucia Hinojosa, Sena Karahan, Fi.Ona

Sound Diaries expands awareness of the roles of sound and listening in daily life. The project explores the cultural and communal significance of sounds and forms a research base for projects executed both locally and Internationally, in Beijing, Brussels, Tallinn, Cumbria and rural Oxfordshire.

The ability to accurately identify and interpret Track and Sign rests on a body of traditional knowledge that previous generations of naturalists would have regarded as fundamental. Sadly, now it is largely unknown and untaught, but with the upsurge of Citizen Science, it is perhaps more relevant than ever.

Slime moulds thrive in damp woodlands and normally spread over rotting logs eating bacteria and fungi. They are also unusual in being single giant cells that show remarkably sophisticated behaviour considering their humble form. This talk presents a little vignette of the science behind these curious beasts and how it has led to better understanding of other networked systems, and even the origins of civilisation.

Join astrophysicist Becky Smethurst on a whistle-stop tour through space, stopping off to explore everything you need to know about the universe. Guiding you through the galaxies, explaining the mysteries of black holes, dark matter and what existed before the Big Bang. She provides evidence as to whether we really are alone and highlighting what we still have to learn. If you have big questions about space or just want to expand your mind join Becky as she provides us with some answers.

Becky’s book Space: 10 things you should know will be available to buy on the night and she will be signing.

‘Bite-sized, cutting edge science delivered with enormous enthusiasm – all you need to travel the cosmos’ CHRIS LINTOTT

Dr Becky Smethurst is an astrophysicist and research fellow at the University of Oxford. Her current research is trying to answer the question ‘How do galaxies and black holes evolve together?’. Her Youtube channel Dr. Becky, where she explains unsolved mysteries, weird objects found in space and general space news each week, has 46k subscribers and counting. She also presents physics videos for YouTube channel Sixty Symbols and astronomy videos for Deep Sky Videos. She was shortlisted for the Institute of Physics Early Career Physics Communicator Award and was named Audience Winner of the UK National Final of the FameLab 2014 Competition.

Astrophysics is the science of the stars, and more widely the science of the Universe. During this stellar event, Prof James Binney will present extracts from his Very Short Introduction to Astrophysics (OUP). You will learn about the rapid expansion of the field in the last century, with vast quantities of data gathered by telescopes exploiting all parts of the electromagnetic spectrum, and the great advance of computing power, which has allowed increasingly effective mathematical modelling.