The advent of super-resolution microscopy has created unprecedented opportunities to study the mammalian central nervous system, which is dominated by anatomical structures whose nanoscale dimensions critically influence their biophysical properties. I will present our recent methodological advances 1) to analyze dendritic spines in the hippocampus in vivo and 2) to visualize the extracellular space (ECS) of the brain. Using a two-photon–STED microscope equipped with a long working distance objective and ‘hippocampal window’ to reach this deeply embedded structure, we measured the density and turnover of spines on CA1 pyramidal neurons. Spine density was two times higher than reported by conventional two-photon microscopy; around 40% of all spines turned over within 4 days. A combination of 3D-STED microscopy and fluorescent labeling of the extracellular fluid allows super-resolution shadow imaging (SUSHI) of the ECS in living brain slices. SUSHI enables quantitative analyses of ECS structure and produces sharp negative images of all cellular structures, providing an unbiased view of unlabeled brain cells in live tissue.

Warburg Memorial Lecture – Joint with BBOWT
Bryophytes in Cambridgeshire have been recorded continuously since 1927 and with increasing intensity in recent decades. A detailed analysis of the records reveals the remarkably dynamic nature of the bryophyte flora of lowland England.

‘Triboreacted materials as functional interfaces in internal combustion engines and medical implants’

Reducing CO2 and particulate emissions to halt global warming and improve the air cleanliness in developed and developing nations is urgent. A similarly large challenge is the provision of medical implants that will serve the ageing population. Both challenges are underpinned by the need to understand important functional interfaces.
This talk will focus on the engine and the hip and will present how an understanding of the interactions between tribology and chemistry/corrosion play a crucial role in the interfacial friction, wear and integrity. The integration of state-of-the-art surface science with engineering simulations in both of these areas enables engineers to create optimised systems with improved performance

Newspapers often feature studies that sound too good to be true and often they aren’t – they are myths.

Some myths may be harmless but the phenomenon affects most kinds of research within evidence-based science. The good news is that there’s a new movement tackling misleading and unreliable research and instead trying to give us results that we can trust.

Using his research in to human pheromones as an example, Tristram will discuss how and why popular myths, including power-posing, are created and how efforts have been made to address the ‘reproducibility crisis’.

Tristram Wyatt is an emeritus fellow of Kellogg College, Oxford and formerly Director of Studies in Biology at OUDCE. He is currently a Senior Research Fellow at the Department of Zoology, University of Oxford. He’s interested in how animals of all kinds use pheromones to communicate by smell. His Cambridge University Press book on pheromones and animal behaviour won the Royal Society of Biology’s prize for the Best Postgraduate Textbook in 2014. His TED talk on human pheromones has been viewed over a million times. His book Animal behaviour: A Very Short Introduction was published by Oxford University Press in 2017.

Open to all. The talk is designed for researchers from all disciplines and is open to the public.

In mammals the cell-autonomous circadian clock pivots around a transcriptional/post-translational feedback loop. However, we remain largely ignorant of the critical molecular, cell biological, and circuit-level processes that determine the precision and robustness of circadian rhythms: what keeps them on track, and what determines their period, which varies by less than 5 minutes over 24 hours? The origin of this precision and robustness is the suprachiasmatic nucleus (SCN) of the basal hypothalamus, the principal circadian pacemaker of the brain. The SCN sits atop a circadian hierarchy that sustains and synchronises the innumerable cell-autonomous clocks of all major organs to solar time (and thereby to each other), by virtue of direct retinal innervation that entrains the transcriptional oscillator of the 20,000 or so component cells of the SCN. I shall describe real-time imaging approaches to monitor circadian cycles of gene expression and cellular function in the SCN, and intersectional genetic and pharmacological explorations of the cell-autonomous and circuit-level mechanisms of circadian timekeeping. A particular focus will be on “translational switching” approaches to controlling clock function and the surprising discovery of a central role for SCN astrocytes in controlling circadian behaviour.

Join us at Teddy Hall next week for a fantastic event on the ‘Neuroscience of Dance’ brought to you by the Centre for the Creative Brain!

Science, dance and wine – what more could you want for a Saturday afternoon?

A few (free) tickets are still available, so be quick!

https://www.seh.ox.ac.uk/discover/research/centre-for-the-creative-brain

Currently limited tools exist to accurately forecast the complex nature of disease spread across the globe. Dr Moritz Kraemer will talk about the dynamic global maps being built, at 5km resolution, to predict the invasion of new organisms under climate change conditions and continued unplanned urbanisation.

Dung beetles in the British Isles are a vital part of their associated ecosystems but have been historically rather overlooked probably due to their chosen habitat. Now our native dung beetles are finally beginning to get some of the invertebrate limelight due to an emphasis on ecosystem services and a much more environmentally friendly farming future. However we are lacking on a great deal of base data about these vitally important species and surveying is the one of the best ways to get information. This means getting into dung and discovering these unsung heroes

The ecology and history of one of the largest atolls in the world. Aldabra, situated in the South West Indian Ocean, supports the largest population of giant tortoises worldwide. A UNESCO World Heritage Site, it is a stronghold for wildlife in a region that is besieged by threats.

Professor Dave Carter reveals how understanding intercellular communication could improve healthcare.

This is a joint event with the Oxford Martin Programme on the Future of Food

Dr Mike Hamm will explore the opportunity for regional food systems in-and-around cities for mutual benefit. He will approach a number of issues – including vertical farming, bio-geochemical cycles, water use, new entry farmers, and healthy food provisioning – embedded in the notion of city region food systems with reference to supply/demand dynamics.

This talk will be followed by a drinks reception, all welcome

Our wild bees and other pollinators are so important, but they are still the unsung heroes of the environment, gardens and countryside and continue to decline in number and range. The talk will identify what we can all do to help wild bees. Many of the actions we take to protect one pollinator species, such as flower rich habitat creation and reduction in pesticide use, will assist biodiversity as a whole.

The high seas are under severe pressure from both direct and indirect human impacts, including the effects of over-fishing, plastic debris and climate change. In this talk, Prof Alex Rogers will present what a network of marine protected areas in the high seas might look like, protecting 30% of known conservation features and taking into account climate change impacts. We will also hear from Dr Gwilym Rowlands, who will consider how such a network of marine protected areas could be enforced and the potential benefits to the ocean.

Dr Larkman is a retired Oxford biologist who has been chairman of OOS for the last 5 years. His main interest is the precipitous decline in the UK’s small, seed-eating farmland birds over the last 50 years.

The ability to accurately identify and interpret Track and Sign rests on a body of traditional knowledge that previous generations of naturalists would have regarded as fundamental. Sadly, now it is largely unknown and untaught, but with the upsurge of Citizen Science, it is perhaps more relevant than ever.

Slime moulds thrive in damp woodlands and normally spread over rotting logs eating bacteria and fungi. They are also unusual in being single giant cells that show remarkably sophisticated behaviour considering their humble form. This talk presents a little vignette of the science behind these curious beasts and how it has led to better understanding of other networked systems, and even the origins of civilisation.

The world scientific community has spent decades developing and refining magnetic confinement fusion theory and experimental devices for the ultimate goal of safely, effectively, and economically generating power from a nuclear fusion reaction.
Magnet systems are the ultimate enabling technology for these types of fusion devices. Powerful magnetic fields are required for confinement of the plasma, and, depending on the magnetic configuration, dc and/or pulsed magnetic fields are required for plasma initiation, ohmic heating, inductive current drive, plasma shaping, equilibrium, and stability control.

Almost all design concepts for power producing commercial fusion reactors rely on superconducting magnets for efficient and reliable production of these magnetic fields.

Future superconducting magnets for fusion applications require improvements in materials and components to significantly enhance the feasibility and practicality of fusion reactors as an energy source.

This lecture presents the fundamentals of superconductors and magnets that makes them attractive for use in fusion device. Examples are drawn from present operating fusion tokamak, helical, and stellarator machines that use low temperature superconductors.

I will also introduce the use of high temperature superconductors for future magnetic fusion devices, and how it may strongly influence the performance of fusion reactors.

This is the 100 year journey to fusion: an award-winning documentary that follows the story of dedicated fusion scientists working to build a small sun on Earth, which would unleash perpetual, cheap, clean energy for mankind.
The screening will be followed by a Q&A session featuring fusion researchers.

UPP Members receive a further £2 off listed prices.

This film is rated 15.

Bernard Tucker Memorial Lecture – Joint with Oxford Ornithological Society

Marking the 150th anniversary of the periodic table, Kit Chapman reveals the incredible and often surprising stories behind the discovery of the superheavy elements; how they have shaped the world today and where they will take us in the future. Be introduced to the amazing people whose tireless quest to drive the periodic table forwards has led to scientists rewriting the laws of atomic structure.

IF Oxford is operating a Pay What You Decide (PWYD) ticketing system. This works by enabling you to pre-book events without paying for a ticket beforehand. Afterwards, you have the opportunity to pay what you decide you want to, or can afford. If you prefer, you can make a donation to IF Oxford when you book. All funds raised go towards next year’s Festival.

This talk will describe a class of machine learning methods for reasoning about complex physical systems. The key insight is that many systems can be represented as graphs with nodes connected by edges. I’ll present a series of studies which use graph neural networks–deep neural networks that approximate functions on graphs via learned message-passing-like operations– to predict the movement of bodies in particle systems, infer hidden physical properties, control simulated robotic systems, and build physical structures. These methods are not specific to physics, however, and I’ll show how we and others have applied them to broader problem domains with rich underlying structure.

The talk will provide an overview of dragonflies and their life cycles and habitats as well illustrating a number of species that occur in England including those that are currently colonising from the Continent and increasing in numbers.

In this book talk, Professor Sonia Contera will talk about how Nanotechnology is transforming medicine and the future of biology.

Please register via the link provided. This book talk will be followed by a drinks reception, book sale and book signing, all welcome.

Tara Pirie recalls her three years living in a tent, while tracking and gathering data on these elusive, but beautiful big cats. She is now one of the world’s leading experts on Leopard ecology and conservation.

Warburg Memorial Lecture – Joint with BBOWT
Volunteer-based botanical monitoring has been a mainstay of British and Irish botany for decades, but only recently has a recording scheme for plant communities been established. Dr Pescott outlines the history of this new National Plant Monitoring Scheme, with a particular focus on the challenges and rewards that have been associated with establishing this novel approach in the UK.

In this lecture Sir Paul Nurse will consider some of the fundamental ideas of biology with the aim of identifying principles that define living organisms.

There is a focus on the cell, the simplest unit exhibiting the characteristics of life, but the principles that will be discussed apply to living organisms more generally.