The advent of super-resolution microscopy has created unprecedented opportunities to study the mammalian central nervous system, which is dominated by anatomical structures whose nanoscale dimensions critically influence their biophysical properties. I will present our recent methodological advances 1) to analyze dendritic spines in the hippocampus in vivo and 2) to visualize the extracellular space (ECS) of the brain. Using a two-photon–STED microscope equipped with a long working distance objective and ‘hippocampal window’ to reach this deeply embedded structure, we measured the density and turnover of spines on CA1 pyramidal neurons. Spine density was two times higher than reported by conventional two-photon microscopy; around 40% of all spines turned over within 4 days. A combination of 3D-STED microscopy and fluorescent labeling of the extracellular fluid allows super-resolution shadow imaging (SUSHI) of the ECS in living brain slices. SUSHI enables quantitative analyses of ECS structure and produces sharp negative images of all cellular structures, providing an unbiased view of unlabeled brain cells in live tissue.

Warburg Memorial Lecture – Joint with BBOWT
Bryophytes in Cambridgeshire have been recorded continuously since 1927 and with increasing intensity in recent decades. A detailed analysis of the records reveals the remarkably dynamic nature of the bryophyte flora of lowland England.

‘Triboreacted materials as functional interfaces in internal combustion engines and medical implants’

Reducing CO2 and particulate emissions to halt global warming and improve the air cleanliness in developed and developing nations is urgent. A similarly large challenge is the provision of medical implants that will serve the ageing population. Both challenges are underpinned by the need to understand important functional interfaces.
This talk will focus on the engine and the hip and will present how an understanding of the interactions between tribology and chemistry/corrosion play a crucial role in the interfacial friction, wear and integrity. The integration of state-of-the-art surface science with engineering simulations in both of these areas enables engineers to create optimised systems with improved performance

Newspapers often feature studies that sound too good to be true and often they aren’t – they are myths.

Some myths may be harmless but the phenomenon affects most kinds of research within evidence-based science. The good news is that there’s a new movement tackling misleading and unreliable research and instead trying to give us results that we can trust.

Using his research in to human pheromones as an example, Tristram will discuss how and why popular myths, including power-posing, are created and how efforts have been made to address the ‘reproducibility crisis’.

Tristram Wyatt is an emeritus fellow of Kellogg College, Oxford and formerly Director of Studies in Biology at OUDCE. He is currently a Senior Research Fellow at the Department of Zoology, University of Oxford. He’s interested in how animals of all kinds use pheromones to communicate by smell. His Cambridge University Press book on pheromones and animal behaviour won the Royal Society of Biology’s prize for the Best Postgraduate Textbook in 2014. His TED talk on human pheromones has been viewed over a million times. His book Animal behaviour: A Very Short Introduction was published by Oxford University Press in 2017.

Open to all. The talk is designed for researchers from all disciplines and is open to the public.

In mammals the cell-autonomous circadian clock pivots around a transcriptional/post-translational feedback loop. However, we remain largely ignorant of the critical molecular, cell biological, and circuit-level processes that determine the precision and robustness of circadian rhythms: what keeps them on track, and what determines their period, which varies by less than 5 minutes over 24 hours? The origin of this precision and robustness is the suprachiasmatic nucleus (SCN) of the basal hypothalamus, the principal circadian pacemaker of the brain. The SCN sits atop a circadian hierarchy that sustains and synchronises the innumerable cell-autonomous clocks of all major organs to solar time (and thereby to each other), by virtue of direct retinal innervation that entrains the transcriptional oscillator of the 20,000 or so component cells of the SCN. I shall describe real-time imaging approaches to monitor circadian cycles of gene expression and cellular function in the SCN, and intersectional genetic and pharmacological explorations of the cell-autonomous and circuit-level mechanisms of circadian timekeeping. A particular focus will be on “translational switching” approaches to controlling clock function and the surprising discovery of a central role for SCN astrocytes in controlling circadian behaviour.

Two-thousand and nineteen marks the centenary of the Addison Act, the housing legislation which realised Lloyd-George’s ‘Homes fit for Heroes’ and the start of a nationwide system of state-owned housing that has lasted most of the 20th Century. Half a million homes were promised and a system of open-ended Treasury grants were made available to local councils to build.

One hundred years have now passed since local authorities in the UK where given the responsibility and the resource to provide decent housing for the working person. Whilst the responsibility remains, the conditions under which housing is to be provided have undergone a seismic shift.

Join us from 19.30 – 21.00 on Thursday 21st February as we explore how the cities of London and Oxford are working to meet this responsibility and provide decent housing for working class people.

We’ll be joined by Sian Berry, Co-Leader of the Green Party, Local Councillor for Camden and Chair of the London Assembly’s Housing Committee and Stephen Clarke, Head of Housing and Property Services for Oxford City Council.

Tickets are free but you must register to attend.

We strive to make all events at Open House as accessible as possible. You can read more about the venue on our website. If there is anything we can do to make your visit more comfortable then please do not hesitate to get in touch.

Join us at Teddy Hall next week for a fantastic event on the ‘Neuroscience of Dance’ brought to you by the Centre for the Creative Brain!

Science, dance and wine – what more could you want for a Saturday afternoon?

A few (free) tickets are still available, so be quick!

https://www.seh.ox.ac.uk/discover/research/centre-for-the-creative-brain

Currently limited tools exist to accurately forecast the complex nature of disease spread across the globe. Dr Moritz Kraemer will talk about the dynamic global maps being built, at 5km resolution, to predict the invasion of new organisms under climate change conditions and continued unplanned urbanisation.

Duncan Dollimore, Head of Campaigns, Cycling UK wants to hear our views on local cycle campaigning
Cycling UK has spent the last few months considering how to work with local campaign groups. Duncan is coming to Oxford because he was impressed by the energy at our conference 15 months ago. This is our chance to influence how Cycling UK relates with local groups like Cyclox.

Dung beetles in the British Isles are a vital part of their associated ecosystems but have been historically rather overlooked probably due to their chosen habitat. Now our native dung beetles are finally beginning to get some of the invertebrate limelight due to an emphasis on ecosystem services and a much more environmentally friendly farming future. However we are lacking on a great deal of base data about these vitally important species and surveying is the one of the best ways to get information. This means getting into dung and discovering these unsung heroes

The ecology and history of one of the largest atolls in the world. Aldabra, situated in the South West Indian Ocean, supports the largest population of giant tortoises worldwide. A UNESCO World Heritage Site, it is a stronghold for wildlife in a region that is besieged by threats.

Professor Dave Carter reveals how understanding intercellular communication could improve healthcare.

This is a joint event with the Oxford Martin Programme on the Future of Food

Dr Mike Hamm will explore the opportunity for regional food systems in-and-around cities for mutual benefit. He will approach a number of issues – including vertical farming, bio-geochemical cycles, water use, new entry farmers, and healthy food provisioning – embedded in the notion of city region food systems with reference to supply/demand dynamics.

This talk will be followed by a drinks reception, all welcome

This lecture is being given by social responsibility expert, Professor Andy Westwood – the former President of the OECD’s Forum for Social Innovation and an adviser at the IMF. Andy is Professor of Government Practice and Vice Dean of Humanities at the University of Manchester and a Visiting Professor of Further and Higher Education at the University of Wolverhampton.

Our wild bees and other pollinators are so important, but they are still the unsung heroes of the environment, gardens and countryside and continue to decline in number and range. The talk will identify what we can all do to help wild bees. Many of the actions we take to protect one pollinator species, such as flower rich habitat creation and reduction in pesticide use, will assist biodiversity as a whole.

The high seas are under severe pressure from both direct and indirect human impacts, including the effects of over-fishing, plastic debris and climate change. In this talk, Prof Alex Rogers will present what a network of marine protected areas in the high seas might look like, protecting 30% of known conservation features and taking into account climate change impacts. We will also hear from Dr Gwilym Rowlands, who will consider how such a network of marine protected areas could be enforced and the potential benefits to the ocean.

Organised by Oxford Civic Society @oxcivicsoc. Government proposals for significant growth in Oxfordshire in coming decades include an Expressway and several new communities. Are these needed or can growth be directed elsewhere? Can growth be ‘intelligent’, leading to prosperity without compromising the quality of life? In the third and final debate to mark the 50th anniversary of Oxford Civic Society, Councillor Ian Hudspeth, Leader of Oxfordshire County Council, and Danny Dorling, Halford Mackinder Professor of Geography in the University of Oxford will contest the issues.. https://www.oxcivicsoc.org.uk/programme/

Dr Larkman is a retired Oxford biologist who has been chairman of OOS for the last 5 years. His main interest is the precipitous decline in the UK’s small, seed-eating farmland birds over the last 50 years.

The ability to accurately identify and interpret Track and Sign rests on a body of traditional knowledge that previous generations of naturalists would have regarded as fundamental. Sadly, now it is largely unknown and untaught, but with the upsurge of Citizen Science, it is perhaps more relevant than ever.

Slime moulds thrive in damp woodlands and normally spread over rotting logs eating bacteria and fungi. They are also unusual in being single giant cells that show remarkably sophisticated behaviour considering their humble form. This talk presents a little vignette of the science behind these curious beasts and how it has led to better understanding of other networked systems, and even the origins of civilisation.

Bernard Tucker Memorial Lecture – Joint with Oxford Ornithological Society

David Miles, former Chief Archaeologist at English Heritage and former Director of the Oxford Archaeological Unit, will be with us here at Blackwell’s to discuss his latest book, The Land of the White Horse: Visions of England.

Synopsis

The White Horse at Uffington is an icon of the English landscape – a sleek, almost abstract figure 120 yards long which was carved into the green turf of the spectacular chalk scarp of the North Wessex Downs in the early first millennium bc. For centuries antiquarians, travellers and local people speculated about the age of the Horse, who created it and why. Was it a memorial to King Alfred the Great’s victory over the heathen Danes, an emblem of the first Anglo-Saxon settlers or a prehistoric banner, announcing the territory of a British tribe? Or was the Horse an actor in an elaborate prehistoric ritual, drawing the sun across the sky? The rich history of this ancient figure and its surroundings can help us understand how people have created and lived in the Downland landscape, which has inspired artists, poets and writers including Eric Ravilious, John Betjeman and J.R.R. Tolkien.

The White Horse itself is most remarkable because it is still here. People have cared for it and curated it for centuries, even millennia. In that time the meaning of the Horse has changed, yet it has remained a symbol of continuity and is a myth for modern times.

This event will take place in the History Department on the second floor. It is free to attend, but please do register to let us know you are coming. For more information call our Customer Service Department on 01865 333 623 or email events.oxford@blackwell.co.uk

The talk will provide an overview of dragonflies and their life cycles and habitats as well illustrating a number of species that occur in England including those that are currently colonising from the Continent and increasing in numbers.

In this book talk, Professor Sonia Contera will talk about how Nanotechnology is transforming medicine and the future of biology.

Please register via the link provided. This book talk will be followed by a drinks reception, book sale and book signing, all welcome.

Tara Pirie recalls her three years living in a tent, while tracking and gathering data on these elusive, but beautiful big cats. She is now one of the world’s leading experts on Leopard ecology and conservation.

Warburg Memorial Lecture – Joint with BBOWT
Volunteer-based botanical monitoring has been a mainstay of British and Irish botany for decades, but only recently has a recording scheme for plant communities been established. Dr Pescott outlines the history of this new National Plant Monitoring Scheme, with a particular focus on the challenges and rewards that have been associated with establishing this novel approach in the UK.